早产儿血胃泌素-胃动素及胃酸动态监测胃肠功能障碍.docVIP

早产儿血胃泌素\胃动素及胃酸动态监测胃肠功能障碍[摘要] 目的 了解早产儿合并出现发胃肠功能障碍的临床特点， 观察血胃泌素，胃动素及胃酸动态的变化对早产儿消化运动功能的影响。 方法 对我院2009年1月-2011年4月入院的28例早产儿引起胃肠功能障碍的患儿及30例正常足月儿的临床资料进行了评估。应用放射免疫分析检测胃泌素、胃动素，胃液基础酸排量检测。监控第1，3，5，7天的胃泌素、胃动素、胃酸的变化。结果 第1，3，5，7天胃泌素下降，早产儿血清胃泌素、胃动素浓度明显低于正常足月儿，差异显著，有统计学意义(p0.05)。结论 早产儿的胃肠动力障碍与神经体液调节异常有关。对早产儿应警惕胃肠功能障碍，降低病死率。 关键词: 血胃泌素 胃动素、胃酸动态监测 早产儿 胃肠功能障碍 Stomach secrete element, premature blood meal and stomach acid dynamic monitoring dynamic gastrointestinal dysfunction [abstract] objective: to understand the merger occurrence hair premature the clinical characteristics of gastrointestinal dysfunction, stomach secrete element, observed blood meal and stomach acid moving the dynamics of the digestive movement function of the influence of premature. Methods a total January 2009 - April 2011 hospital 28 cases of premature cause gastrointestinal dysfunction 30 cases of children and the clinical data of normal full term is evaluated. Ria application analysis and detection stomach secrete grain, stomach move element, based acids displacement detection closed. Monitor the first 1,3,5,7 days stomach secrete grain, stomach move element, stomach acid changes. Results the stomach secrete meal down 1,3,5,7 days, stomach secrete element, premature serum stomach move significantly below normal meal concentration to full term, a statistically significant difference (p 0.05). Conclusion the gastrointestinal dysfunction and premature humoral regulation about neural abnormal. Premature should be vigilant in gastrointestinal dysfunction, reduce mortality. [keywords] blood stomach secrete element; Gastric move element, hydrochloric acid in gastric juice dynamic monitoring; Premature; Gastrointestinal dysfunction. 中图分类号：R722.6 文献标识码：B 文章编号：1004-7484（2011）06-0065-03 早产儿由于离开母体比较早，胃肠道功能不成熟，常易发生胃肠道功能紊乱，出现喂养不耐受。目前认为，胃肠激素参与新生儿消化道结构与功能的发育和成熟过程[1]，胃肠激素中胃泌素、胃动素如果分泌少。是导致早产儿胃肠道功能紊乱的重要原因[2]，可以造成多个系统器官损害的严重病理过程的疾病。通常出现多脏器功能损害，及时对早产儿窒息引起的胃肠功能障碍做出诊断，早期给予综合治疗，对降低其病死率和具有良好的预后有重要意义[3]。本文检测了28例早产儿及30