婴幼儿肢体缺血预处理及对血管内皮功能的影响 - 临床小儿外科杂志.pdf

·18· ·论著· 婴幼儿肢体缺血预处理及对血管内皮功能的影响 周文武1 陈文娟2 高纪平- 刘平波1 李向阳1 Ischcmic 【摘要】目的探索婴幼儿远隔部位缺血预处理(RemotePreconditioningRIPC)的实施方案 及对血管内皮功能的影响。方法将40例体重7蚝以下的先天性心脏病婴幼儿随机分为预处理组和 对照组。预处理组在左上肢以血压计袖带实施RIPC，以血管超声监测右上肢肱动脉血流介导内皮舒张 Mediated (F10w Dilation，FMD)功能。结果RIPC实施顺利，无并发症；预处理组基础FMD无明显差别， 经缺血再灌注后FMD明显下降，对照组为(8．90±2．12)％，明显低于预处理组的(12．33±2．45)％，P 0．05。差异有统计学意义。结论RIPC可安全应用于婴幼儿，并能明显影响其血管内皮功能。 【关键词】内皮，血管；缺血预处理 in Theeffectsofremoteischemic ofendothelialfunctioninfants·ZHOUWen—伽u preconditioning CHEN 0 ofCcardiothoracic Children’s Wen-juan,GA Surgery，HunanHospital Ji-ping,eta1．Department Changsha，410007，China Tofmda for remoteischemic to waycarrying study 【Abstract】Objective preconditioning(RIPC)and effects 40 than7 Wel琶 the ofRIPCofendothelialfunctionininfants．Methodsinfants less weight kilograms intotwo and case$foreach basic divided groupsrandomly(controlgrouppreconditioninggroup．20 group)．The inboth endothelialfunctionsintheformofflow-mediated on arnls’br们,hial dilation(FMDlrightupper artery wereaflsesflt酬l resolutionultrasound．Thenthe inthe were groups byhigh patientspreconditioninggroupremotely ontheleft arnl$with of3minischemiaand3rain the three preconditionedupper cycles reperfusion；while incontrolwerenot 20 inflationof to