抗骨髓微循环防治骨质疏松症机制初探.docVIP

抗骨髓微循环防治骨质疏松症机制初探 王晓燕，李冠武，常时新2 （上海中医药大学附属岳阳中西医结合医院影像科 200437） 摘要：骨质疏松症作为最常见的代谢骨病，其高发病率、高致残率、高病死率、医疗费用消耗高及低生活质量“四高一低”的特点引起医学界的普遍重视。骨质疏松症的发生机制是多因素的，其确切病理机制尚未完全阐明，这就要求人们从新的视角进一步阐明其致病机制，以便为其有效防治提供新靶点。目前，对骨质疏松症的实验及临床研究相关报道日渐积累，但骨髓微循环在骨质疏松症中的发病机理仍不明确，抗骨髓微循环防治骨质疏松症尚未见相关文献报道，寻求抗骨髓微循环途径防治骨质疏松症的有效中药具有潜在价值。 关键词：骨质疏松症；骨髓微循环；中医药 Preliminary Explore Mechanism of Prevention Osteoporosis through Anti-Bone Marrow Microcirculation WANG xiao-yan, LI guan-wu, CHANG Shi-xin (Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine,Shanghai 200437，China) Abstract: As the most common metabolic bone disease, Osteoporosis has high incidence, high morbidity, high mortality, high medical costs consumption and low quality of life, due to its characteristics of four high and one low has been gaining increased attention in medical field. Pathogenesis of osteoporosis is multifactorial, but the exact mechanism is unknown, this requires people from a new perspective to further clarify its pathogenic mechanisms in order to provide new targets for effective prevention and treatment. Currently, the related reports to Osteoporosis in experimental and clinical research has been increasing accumulation, but the pathogenesis about bone marrow microcirculation in osteoporosis remains unclear, the prevention of osteoporosis through anti-bone marrow microcirculation has not been reported in the literature, seeking the effective Chinese medicine to prevent osteoporosis by anti-bone marrow microcirculation has potential value. Key words: osteoporosis; bone marrow microcirculation; chinese medicine 骨质疏松症（Osteoporosis，OP）是以骨量减少、骨微结构受损为特征[1]，导致骨重塑失衡、骨强度降低和骨折易感性增加[2]，由遗传因素、环境因素以及基因-环境相互作用导致的一种复杂的、多因素的全身性的慢性骨骼疾病[1]。它是一个“无声息的疾病”，往往被人们忽视，直到发生骨折才被察觉[3]，随着人口老龄化的日益加剧，骨质疏松和骨质疏松相关的骨折正迅速成为一个重要的公共卫生问题，并且对于医疗服务资源而言是一个相当大的经济负担[2]。 骨质疏松症相关发病机理 在儿童期，睾酮刺激骨骺纵向和横向生长，而雌激素则诱导骨骺融合；成年期，睾酮继续刺激骨膜生长，而雌激素对于骨小梁骨量和结