甲状腺功能异常及血脂水平相关性.docVIP

甲状腺功能异常及血脂水平相关性[摘要] 目的 研究甲状腺功能异常患者血脂水平紊乱的特点及甲状腺激素与血脂水平的相关性。 方法 根据临床诊断设甲亢组86例、甲减组67例，以正常体检人员36例为对照组，分析各组甲状腺激素与血脂水平的相关性。 结果 三组甲状腺激素检测指标、血脂检测指标差异均有统计学意义（均P 0.05）；游离三碘甲腺原氨酸（FT3）、游离甲状腺素（FT4）与血脂均存在不同程度的负相关，促甲状腺素（TSH）与血脂均存在不同程度的正相关。 结论 甲状腺功能异常常导致脂代谢的紊乱，甲状腺激素水平与血脂水平密切相关。 [关键词] 甲亢；甲减；甲状腺激素；血脂 [中图分类号] R581 [文献标识码] A [文章编号] 1673-7210（2012）08（b）-0091-02 Study on the correlation between abnormal thyroid function and blood lipid level LU Shuangyan BAI Xiaogang XU Jie Department of Internal Medicine, the Affiliated Hospital of Yan’an University, Shaanxi Province, Yan’an 716000, China [Abstract] Objective To study the characteristics the serum lipid level in patients with abnormal thyroid function disturbance and correlation between thyroid hormone and blood lipid. Methods According to the clinical diagnosis of 86 cases were set as hyperthyroidism group, 67 cases were set as hypothyroidism group, and normal physical examination 36 cases as control group, the correlation of thyroid hormone and blood lipid levels of correlation were compared. Results Three groups of detection of thyroid hormones, lipids index detection indicators had statistics difference (P 0.05); three free iodine thyronine (FT3), free thyroxine (FT4) and blood lipids were negatively, thyroid-stimulating hormone (TSH) and serum lipids had different degrees of positive correlation. Conclusion Thyroid function abnormalities often leads to lipid metabolism disorders, thyroid hormone levels and blood lipid levels are closely related. [Key words] Hyperthyroidism; Hypothyroidism; Thyroid hormone; Serum lipid 甲状腺激素（TH）是机体内促进生长发育及调节各类能量物质代谢的重要内分泌激素，其合成、分泌及生物学效应的异常可导致多系统、多器官的疾病，近年来甲亢及甲减与脂代谢紊乱的关系逐渐引起国内学者的关注[1-2]。本研究中笔者回顾性分析了2007年1月～2011年12月我院内分泌科甲状腺功能异常患者153例的病历资料，旨在研究甲状腺功能异常患者血脂水平紊乱的特点及甲状腺激素与血脂的相关性。 1 对象与方法 1.1 研究对象 选择2007年1月～2011年12月我院内分泌科153例甲状腺功能异常患者为研究对象，根据临床诊断分为甲亢组86例，男29例，女57例，平均年龄（38.9±9.3）岁；甲减组67例，男37例，女30例，平均年龄（39.6±8.7岁）；另以正常体检人员36例组成正常对照组，男20例，女16例，平均年龄（38.4±10.2）岁。三组在年龄上比较差异无统计学意义（P ＞ 0.0