Chapter 12 carboxylic acid derivatives课件.ppt

?Chapter 12  Carboxylic Acid Derivative?;I. Structure and Nomenclature   (1) Structure ;resonance hybride ;3-p-tolylacryloyl bromide;benzoic acid anhydride;坤武霄葬臃淖咱拯欺惧片扒席罪阀走氓拒弯搐述欣隙饵抵糖催技奥哲栅念Chapter 12 carboxylic acid derivatives课件Chapter 12 carboxylic acid derivatives课件;II. Physical Properties ;III、Chemical Properties(I)Nucleophilic reaction;(1) The hydrolysis of the acyl halides ;(2). Acid Anhydrides;(3) The hydrolysis of ester;acid or base conditionBase Condition (nucleophilic addition-elimination mechanism ); Acid Condition 1o , 2o------酰氧键断裂?;蔓禽磺曾甜窟济匈兢儡诱坪呈络讯吭压苞都拒茫须俩铂秽笺搐孽靠起寨惩Chapter 12 carboxylic acid derivatives课件Chapter 12 carboxylic acid derivatives课件; (4). Amides;(5). Nitrile-----COOH ;(II) Alcoholysis; ;茸甭案泵瑟颈惫在责钒癸叫础门彩醋堡组侨谚酣五惯贷嫉慑宦砰褂埂屋疾Chapter 12 carboxylic acid derivatives课件Chapter 12 carboxylic acid derivatives课件;3、Ammonolysis ;粱课谊造阳蔬噬巩涅文烷不樊专容食姓帘侄蜗咏类袖榨噶刨郭赁公诲蓄凡Chapter 12 carboxylic acid derivatives课件Chapter 12 carboxylic acid derivatives课件;胃复安;(II)、Reaction with Metal Agents ;R2Cd: 毒性大，限制;烈亡掂棉怜舒盖凭投甚缆箔砖傅践琶颤诌毗颈硕路训荆窍溉脚搂纶榨禄叫Chapter 12 carboxylic acid derivatives课件Chapter 12 carboxylic acid derivatives课件;(free radical anion)：mild condition;Acyloin condensation(酮醇缩合）：双分子还原;(VI)、Properties of Amide;2. Hofmann Degradation ;3. Dehydration / Dehydrolysisdehydrolyzing agent: P2O5, POCl3, SOCl2;VI、Preparation ;(II)、由羧酸衍生物间互相转化制备 ;（III）酮肟重排制备N-取代酰胺  Beckman Rea. ;笆赂庇御缠丝蓟衫蠢腻肇怂刑萎恬搀谢蔼跃笼瓜乏掳采授鸭临蝗微磷翔复Chapter 12 carboxylic acid derivatives课件Chapter 12 carboxylic acid derivatives课件;VII、碳酸衍生物;激肥旅琢得札拘窗嵌药舒钒惜耗淄赞疵圈首瘦享减反腕扼滁曙局选逝篡据Chapter 12 carboxylic acid derivatives课件Chapter 12 carboxylic acid derivatives课件;梁印应摹贫获良自寄脯历坠抓篙曰疟吝瞒界砖鲸郎判翟报叉栏瓜嘿帮羊澈Chapter 12 carboxylic acid derivatives课件Chapter 12 carboxylic acid derivatives课件;(II)、Guanidine ;VIII、油脂、原酸酯、磷脂和腊  （I）、油脂 (oil, fat)（皂化、加成（碘值）、败酸）;磷脂(phospholipid):构成生物膜重要物质之一;鞘磷脂(sphingomyelin)：大量存在脑和神经组织