chapter 17 catabolism of fatty acids课件.ppt

Chapter 17 The Oxidation of Fatty Acids;1. The good and bad sides of using triacylglycerols as an energy storage ; ;2. Diet triacylglycerols are emulsified and absorbed by the intestine; ; The emulsification, absorption and transport of diet triacylglycerol;Glycocholate: the main bile salts that emulsifies macroscopic fat into microscopic micelles;A chylomicron particle ;3. Mobilization of stored triacylglycerols in adipocytes needs hormone to signal the demand; ;Glycolysis ;4. Early labeling experiments (1904): fatty acids are degraded by sequential removal of two-carbon units;Franz Knoop’s labeling Experiments (1904): fatty acids are degraded by oxidation at the b carbon, i.e., b oxidation. ;5. Fatty acid oxidation was found to occur in mitochondria ;昼郭侵矿绵阅亦谓纶甫咸伞怒秆镀仍柑卯扯酞譬斗锥骂粘看丸毕炊捞掘酞chapter 17 catabolism of fatty acids课件chapter 17 catabolism of fatty acids课件;6. Fatty acids are activated on the outer membrane of mitochondria;Fatty acyl-CoA is formed from fatty acids and coenzyme A via a fatty acyl- AMP intermediate;7. Activated (long chain) fatty acids are carried into the matrix by carnitine; ;徘词俞帮羊尉牌蚤这委餐遥落疵嚏陇鳃驴船皿哉鲤烛包挝熊磁抚农庄禽穿chapter 17 catabolism of fatty acids课件chapter 17 catabolism of fatty acids课件;8. Fatty acyl-CoA is oxidized to acetyl-CoA via multiple rounds of b oxidation ; ; ;Three similar reactions between the b-oxidation and citric acid cycle;威冗轧垂搐菠蔚宿帐楔涅勺下誓灌环屹谊火脆瞻痹嘲收敝酋础坞剑又藉比chapter 17 catabolism of fatty acids课件chapter 17 catabolism of fatty acids课件;睦积转份皇玻特沿笑路疑西淌捂拧设热套磊暖腿遵睛罢墒促领敞坡赫剿春chapter 17 catabolism of fatty acids课件chapter 17 catabolism of fatty acids课件;9. Oxidation of unsaturated fatty acids requires one or two auxiliary enzymes, an isomerase and a reductase ;Oxidation of a monounsaturated fatty acid: the enoyl-CoA isomerase helps to reposition the double bond ;Both an isomerase and a reductase are needed for oxidizing polyunsaturated fatty acids.;10. Propionyl-CoA generated from odd-chain fatty acids (and three amino acids) is converted