参宁栓抗炎,镇痛,止痒作用研究.pdf

第22卷第6期 广摇 东摇 药摇 学摇 院摇 学摇 报 Vol.22 No.6 2006年12 月 JOURNAL OF GUANGDONG COLLEGE OF PHARMACY Dec.2006 参宁栓抗炎、镇痛、止痒作用研究 1 2 2 2 江摇 涛 ,唐春萍 ,杨超燕 ,陈艳芬 (广东药学院1.实验动物中心;2.中药药理教研室,广东广州510006) 摘要:目的探讨参宁栓的抗炎、镇痛、止痒作用。 方法 采用二甲苯所致的小鼠耳廓肿胀和角叉菜胶所致大鼠足跖肿胀炎症模 型,热板法和扭体法及磷酸组织胺的致痒试验,观察参宁栓的抗炎、镇痛、止痒作用。 结果 参宁栓对二甲苯所致的小鼠耳廓肿 胀和角叉菜胶所致大鼠足跖肿胀有显著的抑制作用,并能明显提高豚鼠对磷酸组织胺的致痒阈,对由热传导及化学性引起的 疼痛有明显的抑制作用。 结论 参宁栓具有抗炎、镇痛、止痒作用,这些作用为参宁栓治疗湿热下注所致的带下、阴痒症提供 了实验依据和药理学基础。 关键词:参宁栓;抗炎;镇痛;止痒 中图分类号:R965摇 文献标识码:A摇 文章编号:1006-8783(2006)06-0637-03 Study on anti鄄inflammatory,analgesic,and antipruritic effects of Shengning suppository JIANGTao,TANG Chun鄄ping,YANG Chao鄄yan,CHEN Yuan鄄fen (LaboratoryAnimal Center,Guangdong College of Pharmacy,Guangzhou,Guangdong 510006,China) Abstract:Objective To observe the anti鄄inflammatory,analgesic and antipruritic effects of Shengning suppository .Methods Analgesic effectsof Shengning suppository were observed with pain model mice by acetic acid or hot plate test. Anti鄄inflammatory effects were studiedwith ear acute edema model induced by dimethylbenzene in mice and rat foot edema model induced by carrageen, and antipruritic action wasobservedwith allergic pruritic model caused by histamine in guinea pigs. Results Shengning suppository could inhibit foot edema in rats and ear edema in mice. It also prolonged the period of pain reaction caused by hot plate in mice,decreased pain reaction induced with acetic acid and increased itching threshold value in guinea pigs. Conclusion Shengning suppository has obvious anti鄄inflammatory,analgesic,and antipruritic effects. Key words:Shengning suppository;anti鄄inflammatory;analgesic;antipruritic 摇 摇 参宁栓是由苦参、黄柏、蛇床子、野菊花等组成 2摇 方法和结果 的经验方,具有清热燥湿、杀虫止痒的功效,临床用 于治疗湿热下注所致的带下、阴痒等症,疗效确切。 2.1摇 抗炎试验 本文对该药的药效学进行了研究,现报告如下。 2.1.1摇 参宁栓对二甲苯所致小鼠耳廓肿胀的影