高延展性聚合物水分散体的制备与特性研究_杨燕.pdfVIP

学 报 310 JournalofChinaPharmaceuticalUniversity　2009, 40 (4 ):3 10-315 ＊ 杨　燕,朱家壁 ,郑春丽, 陈盛君 (, 210009 ) 　　:制备新型高延展性聚合物水分散体, 用于延展性缓释包衣, 并对其理化性质和缓释包衣性能进行 究。 :采用乳液聚合法, 制备聚合物水分散体; 究其理化性质、成膜能力;考察其衣膜的机械性质和释药行为。:自制 聚合物水分散体 (甲基丙烯酸甲酯-丙烯酸乙酯, 1 2 )具有适宜的理化性质、成膜能力和延展性, 无需增塑剂和加热老化便 能形成高延展性、低黏性的衣膜。制得的阿替洛尔缓释微 丸4 h释药 50%以上, 10 h释药 80%以上, 释药行为在压片前后 无明显变化。:自制高延展性聚合物水分散体适于延展性缓释包衣, 可用于制备缓释微 丸片。 　聚合物水分散体;高延展性;缓释包衣;制备 　R944　　　A　　　1000-504 8(2009)04-0 310-0 6 Preparationandcharacterizationofaqueouspolymerdispersionswithhighflexibility forcoating ＊ YANGYan, ZHUJia-bi, ZHENGChun-l,iCHENSheng-jun InstituteofPharmaceutic,sChinaPharmaceuticalUniversity, Nanjing210009, China Abstrac　tAmi:Topreparenovelaqueouspolymerdispersionswithhighflexibilityforsustained-releasecoating andinvestigatetheirproperties.Methods:Theaqueouspolymerdispersionsweresynthesizedbytheemulsion polymerization.Thephysico-chemicalpropertiesandfiml-formingpotentialofthedispersionswereinvestigated whilethemechanicalpropertiesoftheformedfilmandthedrugreleasebehaviorwhenatenololpelletswerecoa- tedwiththeaqueouspolymerdispersionswereevaluated.Results:Thepreparedaqueouspolymerdispersions (methylmethacrylate/ethylacrylat,e1 2 )werefoundtohaveproperphysico-chemicalpropertie,sexcellentfilm- formingcapabilityandsatisfyingmechanicalproperties.Itcouldformfreefilmwithhighflexibilityandlowviscos- ityinlowtemperatureeveninabsenceoftheplasticizer.Sustainedreleaseofatenololpelletswasachievedwhen thepelletswerecoatedthepolymerdispersions.4 -hand8-hcumulativereleasesweremorethan50% and80%, respectively.Therewasnosignificantdifferenceinreleasebetweenpelletspriortoandpostcompressionofthe coatedpellets.Conclusion:Theresultingaqueouspolymerdispersionscouldbeusedassustained-releasecoating materialwi