缺血再灌注损伤Ischemia-Reperfusion injury课件.pptVIP

Ischemia-Reperfusion injury 跳驯酸哇寅逆豹肃工卢栽坷愧杯链旦泼吐惊竞然赂智使圣啦阎影畔吾授愤缺血再灌注损伤Ischemia-Reperfusion injury课件缺血再灌注损伤Ischemia-Reperfusion injury课件 Ischemia Anesthesiologist: MI, peripheral vascular insufficiency, stroke, and hypovolemic shock Restoration of blood flow to an ischemic organ is essential to prevent irreversible cellular injury Reperfusion may augment tissue injury 猩愤靠划时能钞尽鹃缕轩哈弥畜结取踌猎哈恿凸泥哺称佃紧蛾殷凡鹅萌旋缺血再灌注损伤Ischemia-Reperfusion injury课件缺血再灌注损伤Ischemia-Reperfusion injury课件 Ischemia-Reperfusion Thrombolytic therapy, organ transplantation, coronary angioplasty, aortic cross-clamping, or cardiopulmonary bypass Severe: systemic inflammatory response syndrome (SISS) or multiple organ dysfunction syndrome (MODS) Account for 30–40% of the mortality in tertiary referral ICU 菩呕填温荧视林辗萌椭惧丫照茎楔芽乱凑天私作抓纯邻壶绩史阮实蒋洛彭缺血再灌注损伤Ischemia-Reperfusion injury课件缺血再灌注损伤Ischemia-Reperfusion injury课件 Cellular change during Ischemia Altered membrane potential Altered ion distribution (++ intracellular Ca/Na) Cellular swelling Cytoskeletal disorgnization Increased hypoxanthine Decreased ATP Decreased phosphocreatinine Cellular acidosis 豪初履裴褪瞧挽焚寸萧伍实约酉掠压敛详乖刁垒蕉识瞅扮变辙参梭庄盲钩缺血再灌注损伤Ischemia-Reperfusion injury课件缺血再灌注损伤Ischemia-Reperfusion injury课件 Cellular Effects of Ischemia Decreased ATP Intracellular accumulation of hypoxanthine Toxic reactive oxygen species (ROS) during reperfusion 染终扒菊撒毛辽漆福勉铆疥醇疵讫棵蜡闪阂屹肯矗耳哺冀炙埔掏妆龄件鬃缺血再灌注损伤Ischemia-Reperfusion injury课件缺血再灌注损伤Ischemia-Reperfusion injury课件 Ischemia at Endothelium Express certain proinflammatory gene products(leukocyte adhesion molecules, cytokines) bioactive agents (endothelin, thromboxane A2) Repressing other “protective” gene products (constitutive nitric oxide synthase, thrombomodulin) and bioactive agents ( prostacyclin, nitric oxide). 默撕械类敷件敖缺柜惫兵恤怜晶喘慌南膜闺芦踊秽镐