94例乳腺小管癌的临床病理特征分析.PDF

488 中国肿瘤临床2017年第44卷第10期 ChinJClinOncol2017.Vol.44.No.10 临床研究与应用 · · 94例乳腺小管癌的临床病理特征分析 ① ① ② ① ① 梁晓峰 李利娟 张琦 李昉璇 刘俊田 摘要 目的：探讨乳腺小管癌的临床病理特征、影像学诊断、治疗和预后。方法：收集2006年4月至2012年9月天津医科大学肿 瘤医院经病理确诊的94例乳腺小管癌患者的临床资料，回顾性分析其临床病理、影像学特征及治疗与预后。结果：94例乳腺小 管癌患者中超声检查阳性率为74.5%（70/94），显著高于乳腺X线检查阳性率60.6%（57/94），二者比较差异具有统计学意义（P= 0.043）。乳腺小管癌患者ER、PR阳性率较高，HER-2阳性率较低。乳腺小管癌单纯型PR阳性率95.2%（60/63）显著高于混合型 的80.6%（25/31），混合型的HER-2阳性率37.9%（11/29）显著高于单纯型的17.7%（11/62），二者比较差异均具有统计学意义（均 P0.05）。结论：乳腺小管癌是一种恶性度较低的肿瘤，推荐以保乳治疗为主。因其淋巴结转移率较低，建议肿物较小、复发风险 较低的患者可免除保乳术后放疗，但因存在一定的复发风险，术后影像学随访仍非常重要。 关键词 乳腺 小管癌 乳腺X线检查 超声检查 预后 doi:10.3969/j.issn.1000-8179.2017.10.191 Clinicopathological characteristic analysis of tubular carcinoma of the breast: 94 cases 1 1 2 1 1 Xiaofeng LIANG , Lijuan LI , Qi ZHANG , Fangxuan LI , Juntian LIU Correspondence to: Juntian LIU; E-mail: ljt641024@ 163.com 1Cancer Prevention Center, 2 Breast Pathology Department, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjins Clinical Research Center for Cancer, Tianjin 300060, China Abstract Objective: To explore clinicopathological features, imaging diagnosis, treatment, and prognosis of tubular carcinoma of the breast. Methods: This retrospective study included 94 patients in Tianjin Medical University Cancer Institute and Hospital from 2006 to 2012 aged 27 years or older who were histologically diagnosed with tubular carcinoma of the breast. Collected data comprised clinical characteristics, histopathological features, and breast sonographic and mammographic features of patients. Results: Positive rate of breast sonography reached 74.5% (70/94), which is significantly higher than that of breast mammography examination (60.6%, 57/94) (P=0.043). Patients