核医学-骨和关节（Nuclear medicine - bone and joint）.docVIP

核医学-骨和关节（Nuclear medicine - bone and joint） 1, the developing principle of bone tissue is mainly composed of organic and inorganic salt, which is the main component of hydroxyapatite crystals, its surface area is large, for phosphate and other elements from the body fluid to complete bone metabolism update. 99mTc- phosphonate can complete bone metabolism by chemical adsorption and ion exchange. It can also be directly absorbed by immature collagen and deposited on bone to make it develop. 2, compare with X-ray X-ray: Changes in bone mineral density based on decalcification or calcium deposition Resolution is high (fracture shows best), can show the shape of bone, anatomical structure, density and other information, cheap, simple method. Sensitivity is limited (calcium content changes 50%~70%); functional changes can not be found; The fracture is difficult to diagnose on complex structure; only flat display and local search. Bone imaging: Based on changes in local skeletal blood flow and metabolism The sensitivity is high. It is the best to judge the bone metastasis of the tumor before the X-ray or CT for about 3~6 months; Whole body imaging can be performed. The specificity is poor, and the anatomic changes show far less than the above. Two, indications: Bone metastasis Primary bone tumor Bone removal by bone pain Avascular necrosis of the femoral head Metabolic osteopathy Bone graft osteomyelitis After artificial joint replacement Fine fracture Three, technology Three phase bone imaging: flow imaging, 1min, blood pool imaging, 5min, delayed 3H Primary bone tumor; acute osteomyelitis; avascular necrosis of the femoral head; bone graft survival. Four imaging analysis 1 、 normal imaging: the skeletal distribution of the whole body is symmetrical, but the radioactivity in each part is not uniform. A, bone shadow and kidney shadow were observed; B, considering age and normal physiological variation The concentration of radioactivity in the flat bones of the skull, stern