迷走神经与肺部疾病.pdfVIP

1l8 复旦学报 (医学版) 2()12年 3月 ，39(2) in pulmonary diseases，such as asthma，chronic obstructive pulmonary disease (COPD)，acute respiratorydistresssyndrome (ARDS)，pulmonaryfibrosisand lungcancer．In disease，thenerveis activatedbycytokines，chemokines，andothermediatorsfrom manycelltypestoconveyimmunologic informationtotheCNS，whichmayalterdiseaseoutcome．Activationofthevagusnervealsoreleases neuropeptides to modulate immune cellbehavior and can evoke the cholinergic anti—inflammatory pathwaythatregulateslunginflammation．Understandingtheroleofthevagusnerveinneuro-immune interactionmaycontributesignificantlytotheclinicalmanagementofpulmonarydiseases． [Keywords] vagusnerve； inflammation； lung； neuro—immune Introduction Thevagusnerveisthetenthcranial closelyassociatedwithavarietyofafferentandefferent nerve originating from the medulla． It carries nervefibersfrom varied sources (vagal，spinaland preganglionicfibersthatdescendfrom thecranialvault parabronchia1)[．NEBsplay asignificantrolein cell throughthejugularforamen，runninginthecarotid repairafter injury ．Their secretory productsmay sheath through the neck and into the chest and cause proliferation of fibroblasts，epithelial，smooth abdomen to reach parasympathetic ganglia in the muscle cell and airway remodeling，which is an visceralorgans．Afteractivation，postganglionic fibers importantstep in chronic lung disorders．Thus，they releaseacetyleholine (ACh)toproduceresponses．The may also play an important role in neuroimmune vagusnervealsosendssensoryinformationaboutthese interaction．Pulmonarydiseasesproducemechanicaland organsto thenucleustractussolitariusin thecentral chemicalchangesthat stimulate pulmonary afferent nervoussystem (CNS)throughafferentfibersviathe nerves．Diseasemaychangethecompositionofairway jugularand nodoseganglia．Such a communic