阿西匹林（For Asif）.docVIP

阿西匹林（For Asif） After the hydrolysis and acidification of aspirin, the precipitated white precipitate is Sodium salicylate salicylic acid Acetylsalicylic acid benzoic acid Take a drug amount, adding sodium carbonate solution, boiling for 2min, cool, add dilute sulfuric acid in excess, a white precipitate, and the issue of acetic acid odor, the drug should be Para amino salicylic acid Salicylic acid two ethylamine Aspirin benzoic acid When aspirin is placed in the air for a long time, it is easy to change its color (white to yellowish to red brown to dark brown) Aspirin hydrolysis occurs Aspirin absorbs ammonia gas Aspirin produces decarboxylation Aspirin is hydrolyzed to produce salicylic acid and its phenolic hydroxyl is oxidized to quinone The reason for the change of sodium to reddish brown when placed in the air is that Which contains the inter aminophenol impurities Sodium salicylate is of poor stability The aminophenol is oxidized to a two quinone compound The compounds of the two quinone type also change to 3, 5, 3, 5-, four - hydroxy - quinone The carbonyl stretching vibration in the structure of aspirin (V) for peak position #[3300-2300cm^{-1}]# #[1760cm^{-1}]#, #[1695cm^{-1}]# #[1610cm^{-1}]#, #[1580cm^{-1}]# #[1310cm^{-1}]#, #[1190cm^{-1}]# The specific impurities found in aspirin are Salicylaldehyde salicylic acid benzoic acid Benzaldehyde The Chinese Pharmacopoeia stipulates that the limit of impurities contained in aspirin is 0.001% 0.01% 0.1% 1% The inspection method of free salicylic acid in aspirin: take this product 0.1g, add 1ml of ethanol dissolved, add water to 50ml, immediately diluted ammonium ferric sulfate solution 1ml new formulation, such as color 30s, control liquid and salicylic acid (0.1mg / ml) were prepared with 1ml solution, the color is not darker. The limit of free salicylic acid 0.5% 0.05% 2% 0.01% The method of checking readily carbonized matter in aspirin is Colorimetry Titrimetry in two phases Double phase titration after extrac