正常高值血压患者血清高敏C反应蛋白与尿微量白蛋白的相关性.docVIP

正常高值血压患者高敏C反应蛋白与尿微量白蛋白的相关性 杜佩珊，鹿育萨1（作者单位：030001 太原市，山西医科大学第二临床医学院心内科） 【摘要】 目的 观察正常高值血压患者血清高敏C反应蛋白（hs- CRP）与尿微量白蛋白（ALB）的水平，分析二者之间的相关性。方法 选择正常高值血压110例，对照组为同期体检健康者87例，用ELISA 法分别测定血清hs- CRP、ALB；空腹血糖（FBG）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL）、体重指数（BMI）。结果 正常高值血压组血清hs- CRP、ALB水平显著高于对照组（P0.05）；且存在性别差异，男性显著高于女性（P0.05）。hs- CRP 与ALB呈正相关（P0.01，r=0.47），TC、TG、BMI、FBG 、LDL均与二者呈正相关（P0.05）。结论 正常高值血压患者血清hs- CRP、ALB水平明显升高, 提示机体已存在炎症反应。TC、TG、BMI、FBG 、LDL均是炎症反应的相关因素，雌激素可能对女性心血管系统有保护作用。 【关键词】正常高值血压; 炎症反应; 超敏C反应蛋白;尿微量白蛋白;雌激素 中图分类号R544.1 文献标识码A Association of high- sensitivity C- reaction protein and Albuminuria with prehyper tension DU Pei-shan ,LU Yu-sa.Department of Cardiology, Second Affiliated Hospital, Shanxi Medical University,Taiyuan 030001, China 【Abstract】Objective This study was performed to investigate the changes of serum high- sensitivity C- reactive protein level and Albuminuria level in patients with prehypertension and to investigate the relationship between hs- CRP and ALB. Methods Total FBG ,TC ,TG ,BMI ,LDL; were measured in 110 patients with prehypertension and 87 normal controls. Serum CRP and ALB Concentration was measured by ELISA. Results Prehypertension of serum hs- CRP, urinary albumin concentration was significantly higher than that; and high male than female (P 0.05). hs-CRP, ALB with TC, TG, BMI, FBG, LDL was a positive correlation ( All P0.05) .Conclusion The serum hs- CRP and ALB level are increased obviously in the patient with prehypertension, prehypertension has an inflammation reaction.The elevated levels of TC, TG, FBG, LDL and BMI all correlate with inflammation. Estrogen on the female cardiovascular system may have protective effects 【Key words】PrehypertensionInflammatory reaction;hs- CRP ;Albuminuria; Estrogen 心血管疾病严重影响了人们的生活质量，高血压作为心血管疾病最重要的危险因素，如何对其进行防治受到越来越多医学工作者的关注。高血压诊断标准是人为规定的，实际上高血压与正常血压之间并无明确界线，血压从115/75mmHg（1mmHg=0.133kPa）开始，每增加20/10mmHg，心血管疾病风险增加1倍[1]。尿微量白蛋白和高敏C反应蛋白被广泛认同是机体炎症反应、心血管炎症反应的两个灵敏指标。本文旨在通过观察正常高值血压时尿微量白蛋白和高敏C反应蛋白的水平研究它对心血管系