RCS大鼠病变过程中视网膜电图振荡电位的频域特性分析.docVIP

RCS大鼠病变过程中视网膜电图振荡电位的频域特性分析 谢 晶，陈莹迪，阴正勤，翁传煌 （400038重庆，第三军医大学西南医院全军眼科中心，视觉损伤与再生修复重庆市重点实验室目的观察的暗适应ERG）振荡电位（scillatory potentials, OPs）频域特性。方法生后230、40及60 大鼠各3只采用RETI-scan 系统视网膜电图环形角膜电极不锈钢针状电极强度0dB，通过Matlab提取OPs，分析其频谱特性。结果结论鼠的OPs频域特性。 振荡电位；, Chen Yingdi, Yin Zhengqin,Weng Chuanhuang(Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Key Lab of Visual Damage and Regeneration Restoration of Chongqing, Chongqing, 400038, China) [Abstract] Objective To investigate the characteristics of frequency domain of dark-adapted oscillatory potentials in RCS (Royal College of Surgeons) rats. Methods Different ages（20d, 30d, 40d, 60d）of Rcs-rdy--p﹢rats were involved, each of which was three. Dark-adapted ERG (Electroretinogram) of all the rats were recorded with RETI-scan system. Gold-foil ring cornea electrode was used as the recording electrode and home-made stainless steel needle electrode was used as the reference. The intensity of light was 0 dB. OPs components were extracted by the software Matlab7.0 and the characteristics of OPs were analyzed. Results Compared with the normal rats, the frequency-domain amplitude of RCS rats was significantly reduced (P0.0001) and the high-frequency component was disappeared. With the development of RCS rats, the frequency of the peak amplitude was delayed to the high frequency at 40d, and the amplitude of the peak was reduced significantly (P0.05). Conclusions There was a correlation between the frequency-domain characteristics of OPs and the development of the disease in RCS rats. By using these characteristics, it is possible to know the influences of the disease to the retinal function in RCS rats. [Key words] Electroretinogram; oscillatory potentials; RCS rats; Frequency-domain analysis Supported by the National Basic Research Program of China (973 Program, 2013CB967002). Corresponding author: Yin Zhengqin, Tel:86-23国家重点基础研究发展计划自1933年Granit提出了ERG）的三导程学说，ERG广泛振荡电位（scillatory potentials, OPs）是组重叠在E