ασκησηκαιαπ.ppt

LVH: Causative Factors Heart Rate, Mean Blood Pressure and CFR Changes After Clonidine Infusion Hemodynamic and Humoral Correlates in Essential HTN: Relationship Between Patterns of LVH and Myocardial Ischemia Renin-Angiotensin Aldosterone System Biochemical Results Meta-analysis of randomized, controlled trials of LV hypertrophy regression in essential hypertension Comparison of Spirapril Isradipine and their Combination in HTN Patients with LVH:Effects on LVH Regression and Arrhythmogenic Propensity ISR SPIR ISR+SPIR ACE-Inhibition in HTN Patients is Associated with a Reduction in the Occurrence of Atrial Fibrillation LIFE Study Change in Cornell Voltage Duration Product and Sokolow-Lyon LIFE Study Primary Composite Endpoint Effect of Losartan on Sudden Cardiac Death in People with Diabetes: Data From the LIFE Study Reduction in Risk of Stroke in Patients with AF Ischemic Stroke“Mosaic of Interacting Factors” How Did Losartan Reduce the Risk of Stroke “Beyond Blood Pressure”? Schmieder RE et al. Am J Med 2003; 115:41-6. -16 -14 -12 -10 -8 -6 -4 -2 0 Diuretics ?-blockers Ca- antagonist ACE- inhibitors ARBs -8% -6% -11% -10% -13% LV mass Reduction (%) 80 randomized controlled trials; 4,113 patients % SBP (mmHg) -11.6+8* -11.4+7* -18+10* % DBP (mmHg) -15+18* -14+6* -20+6* % LVMI (g/M2) -7.9+4+ -9.6+8* -7.8+10+ % NE (ng/ml) 31+72 -7.8+70 44+96 *p0.001, +p0.05 % PRA (ng/ml/hr) 186+213 192+267 115+113 % AVP (pg/ml) 236+259 411+772+ 120+336 Manolis AJ et al. Am J Hypertens 1998 PCA: Periarteriolar collagen area TIC: Total Interstitial Collagen * p 0,04 # p 0.001 % Morphological and Haemodynamic changes before and after treatment. Hypertension 2000 Repair of Coronary Arterioles After Treatment with Perindopril in Hypertensive Heart Disease LVMI CBF CVR CR PCA TIC 12% 54% 33% 67% 54% 22% 70 -70 # # # * * * 0 Occurrence of Atrial Fibrillation According to Antihypertension Treatment: IR per 1,000 Person-Years of Atrial Fibrillation – Related Hospitalizati