黄芪对放射性肺损伤干预作用及对tnf-αctgf影响的研究.docVIP

黄芪对放射性肺损伤干预作用及对TNF-α、ET影响的研究 奚蕾，夏德洪，沈伟生，许晨，周剑波，舒中琴，于波，候昕珩，王珂 [摘要] 目的 观察黄芪对局部中晚期胸部肿瘤放射治疗的肺保护作用及对肿瘤坏死因子-α（TNF-α）、内皮素(ET)表达水平的影响。方法 将局部中晚期胸部肿瘤放射治疗者随机分为治疗组和对照组。治疗组在放射治疗开始起服用黄芪10ml， 2次/d，连续6个月。放射治疗前后测定血浆TNF-α和ET，放射治疗开始15天起观察临床症状、高分辨率CT和肺弥散功能。结果 治疗组放射治疗前血浆TNF-α为（1.91±0.46）ng/ml（2.48±0.75）ng/ml（1.90±0.51）ng/ml（5.12±1.01）ng/mlP0.001）。治疗组放射治疗前血浆ET为（57.67±17.32）pg/ml（69.32±23.03）pg/ml（58.93±16.98）pg/ml（97.87±37.83）pg/mlP0.001）。放射治疗开始后5个月和10个月治疗组CO弥散量下降情况较对照组差异有统计学意义（P0.05）。治疗组和对照组急性放射性肺炎和肺纤维化的发生率比较差异有统计学意义（P0.05）。结论 黄芪能抑制放射治疗后血浆TNF-α和ET的过度表达，降低放射治疗后弥散功能的恶化。可以用于放射性肺损伤的治疗和预防。 [主题词] 放射治疗；黄芪；肺损伤；辐射防护；TNF-α；ET The investigation of Astragalus membranaceus on radioprotection of lung and expression of plasma Tumor necrosis factor-α(TNF-α)and Endothelin (ET) Xi Lei Xia Dehong Shen Weisheng Xu Chen Zhou Jianbo Shu Zhongqin YuBo Hou Xinheng Wang Ke ,et al.Jiangyin Hospital of Medical College.Southeast University, Jiangyin 214400, China [Abstact] Objective: To observe the effect of Astragalus membranaceus on radioprotection of lung and expression of plasma Tumor necrosis factor-α(TNF-α)and Endothelin (ET) in partial mid and late stage chest tumor patients with lung radiotherapy . Methods: The partial mid and late stage chest tumor patients were randomized into control group and therapy group, therapy group with Astragalus membranaceus10ml,po,bid before radiotherapy and continued for 6 mouths,Plasma TNF-α and ET were examined before and at the end of radiotherapy,Clinicalsymptoms,lung function and high-resolution computed tomography of thorax were evaluated at 15 days after radiotherapy. Results: Before radiotherapy, plasma TNF-α for（.91±0.46）ng/ml in therapy group and （1.90±0.51）ng/m in control group,at the end of radiotherapy,the level of plasma TNF-α in control group was much higer than in therapy group(5.12±1.01ng/ml vs2.48±0.75ng/mlP0.001）,before radiotherapy, plasma for（57.67±17.32）pg/ml in therapy group and （58.93±16.98）pg/ml in control group,at the end of radiotherapy