新生儿败血症的病原菌及耐药性分析.PDFVIP

5·72 · Chin J Nosocomiol Vol. 13 No. 6 2003 ·论 　著· 新生儿败血症的病原菌及耐药性分析 杨锦红 , 李向阳 , 张楚南 (温州医学院育英儿童医院 ,浙江 温州 325027) 摘要 : 目的 　了解近 10 年新生儿败血症的病原菌分布及其耐药状况。方法 　对 1991～2000 年我院新生儿血培 养结果进行分析和总结。结果 　859 例阳性标本中表皮葡萄球菌和金黄色葡萄球菌分别占 32. 9 %和 16. 1 % ,对 多种抗生素耐药 ,苯唑西林的耐药率分别为 67. 6 % 、70. 5 % ,对万古霉素 100 %敏感 ;革兰阴性菌中大肠埃希菌占 首位 ,其次为肺炎克雷伯菌、肠杆菌属、假单胞菌属 ; 抗菌活性较好的药物是亚胺培南、阿米卡星、环丙沙星。 结论 　葡萄球菌是新生儿败血症的主要病原菌 ;新生儿败血症的病原菌具多重耐药性 ,应积极防治。 关键词 : 新生儿败血症 ;病原菌 ;耐药性 中图分类号: R515. 3 　　文献标识码 : A 　　文章编号 : (2003) Pathogens Causing Ne wborn ′Septicemia and Their Antibiotic Resistance YAN G Jinhong ,L I Xiangyang , ZHAN G Chunan ( Y uyin g Pediat ric Hospital , Wenz hou Medical College , Wenz hou 325027 , China) Abstract: OBJECTIVE To learn the distribution of pathogens causing newborn′septicemia and their antibiotic resistance . METHODS The results in blood culture of newborns in our hospital from 1991 to 2000 were analyzed. RESULTS Among 859 positive samples of blood culture , positive ratio of S taphylococcus epidermidis and S . aureus were 32. 9 % and 16. 1 % , respectively. Furthermore , they were multiresistant. The ratio of meticillinresistant S . epidermidis and S . aureus was 67. 6 % and 70. 5 % , respectively , but all were sensitive to vancomycin. Among Gram negative bacteria , Escherichia coli was in the first place , the second one was Klebsiella pneumoniae , the others were Enterobacter , Pseudomonas spp. The better antibiotics for them were imipenem , amikacin , and ciprofloxacin. CONCL USIONS S taphylococcus spp is one of the main pathogens causing newborn′septicemia. These pathogens were multiresistant , and some measures against them