雌激素对心血管作用的分子基础（The molecular basis of cardiovascular effects of estrogen）.doc

雌激素对心血管作用的分子基础（The molecular basis of cardiovascular effects of estrogen） The molecular basis of cardiovascular effects of estrogen Review of 2011-07-21 Liu Jianguo Wu Saizhu. [Abstract] estrogen has protective effects on cardiovascular system of women, the main effect is through the activation of estrogen receptor (ER), thereby affecting the expression of the target tissue gene, which exerts its biological effects. ER were distributed in different tissues in the cardiovascular system, mediated by ER estrogen on vascular endothelial cells, vascular smooth muscle cells, myocardial cells have different degrees of regulation. [Key words] estrogen estrogen receptor gene transcription in vascular smooth muscle cells in vascular endothelial cells Since people found that women with estrogen protect the cardiovascular system, the prevention of atherosclerosis and coronary heart disease (AS), basic and clinical studies on the mechanism of estrogen are focused on estrogen and lipid metabolism and vascular wall directly, but studies have shown that single explain the anti AS effect of estrogen in blood lipid changes not at present, that the only part of the cardiovascular protective mechanism of estrogen 1. With the in-depth study, now that the molecular basis of estrogen target cells in target cells in a memory, estrogen receptor and its specific binding component (ER), many known estrogen are mediated by ER. Nearly ten years of research shows that widely distributed in the cardiovascular system also has ER, part of the cardiovascular effects of estrogen are mediated by ER, which provide a molecular foundation to explain the effects of estrogen on cardiovascular physiology and pathology process. As the molecular basis of cardiovascular effects of estrogen on ER is becoming a hot topic of this paper, the structure of ER, classification, detection, activation, distribution and dielectric in cardiovascular research guide summarized the advances in cardiovascular effects. The str