蛋白质二硫键异构酶的生物学功能研究进展.PDFVIP

92 中国循环杂志 2015 年 1 月 第 30 卷 第 1 期（总第 199 期）Chinese Circulation Journal，January，2015，Vol. 30 No.1（Serial No.199） cause and effect of sodium-sensitive hypertension. Clin Exp Nephrol, [29] Williams JE, Nieto FJ, Sanford CP, et al . Effects of an angry 2010 , 14: 105-111. temperament on coronary heart disease risk: The atherosclerosis risk in [26] Cuttica MJ, Langenickel T, Noguchi A, et al. Perivascular T-cell communities study. Am J Epidemiol. , 2001, 154: 230-235. infiltration leads to sustained pulmonary artery remodeling after [30] Zhaodi Niu, J ian Zhou, Wenwu Ji, et al. The Association of endothelial cell damage. Am J Respir Cell Mol Biol, 2011 , 45: 62-71. psychological stress related cytokines (TNF Alpha, IFN-Gamma) [27] De Miguel C, Guo C, Lund H, et al. Infiltrating T lymphocytes in the with essential hypertension in ningxia hui autonomous region. Open J kidney increase oxidative stress and participate in the development Endocr Metab Dis, 2013, 3: 276-282. of hypertension and renal disease. Am J Physiol Renal Physiol, 2011, [31] Granger JP, Alexander BT, Llinas MT , et al. Pathophysiology of 300: F734-F742. hypertension during preeclampsia: Linking placental ischemia with [28] Wallace K, Richards S, Dhillon P, et al. CD4+ T-helper cells endothelial dysfunction. Hypertension, 2001, 38: 718-722. stimulated in response to placental ischemia mediate hypertension ( 收稿日期 : 2014-06-23） during pregnancy. Hypertension, 2011 , 57: 949-955. （编辑：常文静 ） 综述 蛋白质二硫键异构酶的生物学功能研究进展 * 潘黎明、盛梦婷、黄子芮综述， 李俊明审校 摘要 蛋白质二硫键异构酶由多种细胞分泌，在生物学代谢过程中具有重要作用，其与糖尿病缺血性心脏病、脑 缺血性疾病、血栓性疾病、阿尔茨海默病、白血病、肿瘤等多种疾病的发生发展机制密切相关，现针对蛋白质二 硫键