Graves病患者131I治疗前后血清TNF-α和TRAb水平的变化及其相关性研究.docVIP

Graves病患者131I治疗前后血清TNF-α和TRAb水平的变化及其相关性研究 郭 莲，张先祥 （404000 重庆，重庆三峡中心医院内分泌科） [摘要] 目的 观察Graves病患者131I治疗前后血清肿瘤坏死因子-α（TNF-α）和促甲状腺激素受体抗体（TRAb）水平的变化及其相关性，探讨TNF-α、TRAb与Graves病发病机制的关系及在131I治疗Graves病中的应用价值。方法 120例131I治疗的Graves病患者作为治疗组,另设60例健康人作为对照组。采用放射免疫分析法（RIA）、酶联免疫吸附法（ELISA）检测对照组与治疗组治疗前及治疗后3、6、18个月的FT3、FT4、TSH、TNF-α、TRAb水平，并进行对比分析。 结果 治疗组治疗前与对照组比较,FT3、FT4、TNF-α、TRAb均有明显升高，TSH明显降低，治疗后3、6、18个月各指标逐渐改善，均有显著差异（P0.05），治疗后18个月FT3、FT4、TSH指标[分别为（4.61±0.87）、（15.71±5.22）pmol/L，（2.89±0.62）μIU/L]接近对照组水平，差异无统计学意义（P0.05），TNF-α、TRAb[（2.42±1.22），（18.27±1.53）]高于对照组水平，差异有统计学意义（P0.05）；治疗组治疗前及治疗后3、6、18个月TNF-α、TRAb水平呈显著正相关（P0.05）。结论 131I治疗可有效恢复甲状腺功能 [关键词] Graves病；131I治疗；TNF-α；TRAb [中图法分类号] [文献标志码] A [通信作者] 张先祥，电话：（023E-mail:zxx8881@163.com Changes and correlation of Serum TNF-α and TRAb in patietns with Graves disease before and after 131I Treatment Guo Lian, Zhang XianXiang （Department of Endocrinology, Chongqing Three Gorges Central Hospital, Chongqing ，404000，China） [Abstract] Objective To explore the changes and correlation of serum tumor necrosis factor-α（TNF-α）and anti- hyrotropin receptor antibody ( TRAb) in patients with Graves disease before and after 131I treatment and to detect the applied value of TNF-α and TRAb in 131I treatment of Graves disease. Methods 120 patients were diagnosed with Graves disease and treated with 131I as treatment group. respectively. 60 age- and sex-matched healthy subjects served as control group, and the results were compared with that of the control group. Serum FT3，FT4，TSH，TNF-αand TRAb levels in control group and treatment group at before131I therapy, 3 month,6 months and 18 months after treatment were measured by using radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) and Comparison ,analysis were made.Results Serum levels of FT3、FT4、TNF-α、TRAb (P0.05) in The treatment group before treatment were significantly higher and levels of TSH were significantly decreased (P0.05) compared with the control g