5%硫磺溶液结合强脉冲光治疗中重度痤疮疗效观察.docVIP

5%硫磺溶液结合强脉冲光治疗中重度痤疮疗效观察[摘要]目的：观察5%硫磺溶液联合强脉冲光(1PL)治疗寻常性痤疮的疗效及安全性。方法：将229例寻常性痤疮患者随机分成两组，两组均外涂5%硫磺溶液至患处，2次／日，4周为1个疗程。治疗组采用强脉冲光治疗仪治疗，每周1次，连续4次为1个疗程；对照组口服维胺酯胶囊25mg,3次／日，4周为1个疗程。结果：治疗组有效率为83.08%，对照组总有效率为72.04%，两组比较有显著性差异(P＜0.05)，治疗组副作用包括短暂且可耐受的轻微红肿、发热或局部刺痛感。结论：5%硫磺溶液结合强脉冲光照射治疗寻常性痤疮优于维胺酯胶囊治疗，是一种可选择用于治疗中重度痤疮的较安全、有效的方法。 [关键词]强脉冲光；寻常性痤疮；维胺酯 [中图分类号]R758.73+3 [文献标识码]A [文章编号]1008-6455（2011）10-1592-03 Efficacy and safety of intense pulsed light therapy in combination with lotion 5 percent sulphur in the treatment of acne vulgaris PENG Sheng-chi,LI Yu-liang,CHEN Jing （Department of Dermatology, The People’s Hospital of Pingxiang, Pingxiang 337055,Jiangxi,China） Abstract:ObjectiveTo observe the efficacy and safety of intense pulsed light(IPL) therapy in combination with lotion 5 percent sulphur in the treatment of acne vulgaris. MethodsPatients with acne vulgaris were divided randomly into two group. The patients in the IPL group accepted the treatment of intense pulsed light, once a week for 4weeks;while the others in the control group were treated with Viaminate at 25mg, three times a day for 4 weeks; Both of them accepted the treatment of lotion 5 percent sulphur twice a day for 4 weeks.ResultsThe effective rate of IPL group was 83.08%, while that of the control group was 72.04%.There was significant difference(P＜0.05)between two groups. Conclusion Intense pulsed light(IPL) therapy in combination with lotion 5 percent sulphur is an effective and safe treatment method for the patients with acne vulgaris Key words：Intense pulsed light(IPL);acne vulgaris;viaminate;lotion sulphur 痤疮是一种常见的毛囊皮脂腺慢性炎症性皮肤病，多出现于青春期男女的颜面及胸背部，可形成丘疹、结节、脓疱、硬结、囊肿以及增生性瘢痕等，对患者工作和生活都产生较大的影响，传统的治疗方案以药物治疗为主。随着痤疮丙酸杆菌耐药性的增加和患者对药物副作用的担忧，大部分患者趋于选择非药物治疗。近年来，笔者科室采用强脉冲光联合硫磺洗剂治疗痤疮获得了较好疗效，现将结果报道如下。 1资料和方法 1.1 一般资料：所选229例均为门诊确诊的痤疮患者，将患者随机分为两组：治疗组136例，其中男78例，女58例，年龄18～30岁，平均为(22.10±3.34)岁，病程1～7年，平均(3.16±1.88)年：对照组93例，其中男56例，女37例，年龄18～32岁，平均(21.10±3.52)岁，病程l～6年，平均(3.26±1.76)年。两组年龄、性别、病情严重程度分级比较无显著