复方卡力孜然酊联合窄谱中波紫外线治疗颜面部白癜风临床观察.docVIP

复方卡力孜然酊联合窄谱中波紫外线治疗颜面部白癜风临床观察[摘要]目的:评价外用复方卡力孜然酊联合窄谱中波紫外线(NB-UVB)治疗颜面部稳定期白癜风的临床疗效及安全性。方法:将120例面部白癜风患者随机分成三组:A组:外用复方卡力孜然酊联合NB-UVB照射;B组:单独给予NB-UVB照射;C组:单独外用复方卡力孜然酊。疗程均为12周,治疗结束时依据治疗前、后患者皮损照片进行疗效评价。结果:治疗结束后,A、B、C三组有效率分别为78.6%、48.1%、51.9%,A组有效率与B、C两组相比,差异均有统计学意义(均P0.05)。结论:复方卡力孜然酊联合NB-UVB治疗面部稳定期白癜风起效快、疗效好,安全可靠。 [关键词]白癜风;复方卡力孜然酊;窄谱中波紫外线 [中图分类号]R758.4+1 [文献标识码]A [文章编号]1008-6455(2010)09-1346-02 Combination of Fufang kali ziran ding and NB-UVB for vitiligo on the face ZENG Wen-jun, WANG Liu-jun (Department of Dermatology,People’s Hospital of Changping,Dongguan 523573,Guangdong,China) Abstract:ObjectiveTo evaluate the efficacy and safety of Fufang kali ziran ding and NB-UVB for the treatment ofstable vitiligo on the face.MothodsA randomized experimental controlled study was performed in 120 patients, they were randomly divided into three groups:group A,receiving Fufang kali ziran ding as well as NB-UVB therapy;group B,singly receiving NB-UVB therapy;group C,singlyreceiving Fufang kali ziran ding.All patients were treated for 12 weeks. Efficacy was analyzed using digital photography taken before and after treatment.ResultsAfter therapy,the response rates were 78.6%,48.1%and 51.9% respectively in group A, B and C.The response rate was higher in group A than in group B and C (P0.05).ConclusionsThe combinnation use of Fufang kali ziran ding and NB-UVB is effective and safe in the treatment of vitiligo on the face. Key words:vitiligo; Fufang kali ziran ding; narrow band ultraviolet B 白癜风是一种临床常见的色素脱失性皮肤病,而颜面部白癜风则严重影响人们的审美、工作及生活,给患者带来较大的心理负担,故求治心切。目前,其病因和发病机制不明,以往采用多种方法治疗效果均不甚理想。2008年1月～2010年1月,我们采用复方卡力孜然酊联合窄谱中波紫外线(NB-UVB)治疗面部稳定期白癜风患者,取得了较好疗效,现报道如下。 1 一般资料和方法 1.1临床资料:选择2008年1月～2010年1月就诊于我科的颜面部稳定期白癜风患者120例,其中女62例,男58例,年龄20～55岁,平均35.5岁,病程6月～4年,皮损面积:0.5m×1cm～4cm×5cm。入选标准:①临床诊断为白癜风,6个月内皮损无变化;②2个月内未行系统治疗,2周内未进行局部治疗;③签署知情同意书并严格接受治疗方案;④无严重心、肝、肾及其他系统疾病者。排除标准:①紫外线禁忌证;②妊娠、哺乳期妇女;③对所用药物过敏者;④皮疹局部合并细菌或真菌感染者。 1.2 治疗方法: 采用实验对照法,将120例患者随机分为三组。三组患者的性别、年龄、病程及病期等经方差分析,差异