非洛地平对oxLDL损伤的人脐静脉内皮细胞一氧化氮合酶mRNA及一氧化氮表达的影响.docVIP

　　非洛地平对oxLDL损伤的人脐静脉内皮细胞一氧化氮合酶mRNA及一氧化氮表达的影响 【关键词】 非洛地平;一氧化氮合酶;一氧化氮;动脉粥样硬化 ABSTRACT: Objective To investigate the protective effects of felodipine on mRNA levels of endothelial nitricoxide synthase (eNOS) and inducible nitricoxide synthase (iNOS) as onoxidum (NO) from human umbilical vein endothelial cells (HUVECs) injuryed by oxidized log/L), and intervention group of felodipine (0.1, 1.0 and 10μmol/L)+oxLDL (25mg/L). Then eNOS and iNOS expressions easured by real timepolymerase chain reaction and the level of NO in the supernatants of the cultures ethod. Results The mRNA expressions of e