大剂量咪唑立宾联合环孢素预防肾移植术后巨细胞病毒感染：随机对照.pdfVIP

? 震临床医学 J 中国组织工程研究与l艋床康复笫』2誊笫 婀2008一O卜29出版 ournal ofClinical Rehabilitative Tissue Engineering Research January 29，2008 Vo1．12，No．5 大剂量咪唑立宾联合环孢素预防肾移植术后巨细胞病毒感染：随机对照★ 詹胜利，蔡 明，石炳毅，李州利，韦 星，王 爽 Large-dose mizoribine in combination with cyclosporine prevents cytomegalovirus infection after kidney transplantation：A randomized controlled study Zhan Sheng-li，Cai Ming，Shi Bing-yi，Li Zhou-li，Woi Xing．Wang Shuang Abstract Department of AIM：／n vitro study demonstrated that large dose of mizoribine can inhibit cytomegalovirus replication．The study was aimed to Urinary Surgery,the analyze whether maximum allowable dose mizoribine combined with cyclosporine depressed the incidence of cytomegalovirus 3o9 Clinical Depart- infection and the maximum allowable dose mizoribine security in kidney transplantation recipients． ment of General Hospital of Chinese METHoDS： Thirty patients who received kidney transplantation were enrolled at Department of Urinary Surgery．309 Clinical PLA， Beijing Department of General Hospital of Chinese PLA from June 2006 to February 2007．AII patients singed informed consents of the 1O。0睁1．China experiment and treatment scheme．The experiment was approved by Hospital Ethical Committee．②Thirty recipients were Zhall Sheng—li★ ． assigned into 2 groups．Patients in a mizoribine group(n=15)were treated with cyclosporine(CSA)，mizoribine(MZR)and Master, Attending prednisone(Pred)；and patients in a control group =15)were treated with CSA，mycophenolate mofetil(MMF)and Pred．⑨The physician， Depart— incidence of 90-day cytomegalovirus infection，acute rej。ection．bone malTOW depression and hyperuricacidemia were observed ment of Urinary after transplantation． Su~ery, the 3O9 Clinical Department RESULTS：Thirty recipients were included