骨形态发生蛋白2在骨质疏松症大鼠骨折愈合过程中的表达.pdfVIP

中国组织工程研究与临床康复第12 者第2 JfI! 2008 - 01 - 08 出版 @烹忘我基础重学 Journal 01 Clinical Rehabilitative 1issue Engineering Research January 8. 2008 Vol. /2. No.2 骨形态发生蛋白2在骨质疏松症大鼠骨折愈合过程中的表达忖食 唐尤超，王远勤，林和平，邹志根 Expression of bone morphogenetic protein-2 during fracture heaUng in osteoporotic rats Tang You-chao , Wang Yuan叫ìn， Lìn He-pìng , ZOU 2hì-gen Abstract Dφartment 01 AIM: Mesenchymal cells migrating towards fracture site and differentiating into chon命ocytes and ωteoblasts is the key proc臼S Dentofacial Su皂白y， during fracture healing.ηlÏs article is aimed to observe the changes ofthe expression ofbone morphogenetic protein (BMP)-2 in 出e Huizhou Ston盟tology 四rly stage oftibia fracture in osteoporotic rats so as to evaluate the reason of delayed fracture healing in osteoporotic rats. Hospital. Huizhou METHODS: The experiment was conducted at the Key Laboratory for Oral Biomedical Engineering ofMinistry ofEducation 台om 516∞1. Guangdong Provin田. China AUgl以 2005 to October 2006. ( Sixty-four 6-month-old female SD rats were randomly divided into ovariectomized (OVX) group and control group with 32 in each group. (The rats in 出e OVX group underwent ovariectomy to 臼tablish type 1 osteoporotic Tang You-chao 食， models. A small quantity of fat tissues was removed in the control group. Three months later, standardized tibia 企-acture was Doctor. As跃ciate chief physicia n, introduced. ( Eight rats were selected at days 7 , 14, 21 and 28 after operation in the two groups. Some soft tissu臼 around tibia and Dφartment 01 broken ends of fractured bone , bony callus, cortical bone and medullaryωnal were collected and treated with histological analysis , Dentofacial S