紫外辐射引起DNA损伤的修复.pdfVIP

7 综 述 J 中国组织工程研究与临床康复第J2誊第2 2008一O卜O8出版 ournal ofClinical Rehabilitative Tissue Engineering Research January2008 Vo1．12，No．2 紫外辐射引起DNA损伤的修复★★ 王 睿，郭周义，曾常春 Repair of DNA lesions induced by ultraviolet irradiation Wang Rui，Guo Zhou-yi，Zeng Chang-chun Abstract Laboratory of BACKGROUND：Ultraviolet(UV1 radiation causes DNA lesion in human epiderma1．It also activates enzymes in epidermal cells to Photonic Chinese start the repair of DNA lesion． Medicine， Key OBJECT1VE：To analyze and review the research advances in the repair mechanisms of DNA lesions induced by ultraviolet Laboratory 0f Laser Life Science of radiation． Ministry of RETRIEVAL STRATEGY：A computer-based online search of PubMed was undertaken to identify articles about DNA damage Education， South repair and DNA damage caused by ultraviolet radiation published in English between January l99l and August 2007 with the China Nollnal keywords of”UV．induced DNA damage and DNA repair”in the title and abstract．The articles about DNA damage and UV．induced University, Guangzhou DNA damage were selected．nle articles with similar content published recently or in authorized iournals were preferred． 5 lO63 I． Guangdong LITERATURE EVALUAT10N：56l articles were collected．and 42 ofthem were accorded with the inclusive criteria． Province，China DATA SYNTHESIS：With the increase of ultraviolet radiation caused by environmental pollution，DNA in human epidermal cells is Wang Rui ★ ． damaged．Cyclobutane pyrimidine dimmer(CPD)and 6-4 photoproducts ale the main forms of DNA lesions．Ultraviolet-visible light Studyhag for masters can activate DNA photolyase．which can break the ring of CPDs to repair DNA le