基于体素的形态学MRI观察未经药物治疗的强迫症患者脑灰质结构改变.docVIP

DOI：10.16016/j.1000-5404.201411007 基于体素的形态学MRI观察未经药物治疗的强迫症患者脑灰质结构改变 张 杨，侯景明，武文婧，黎海涛（400038重庆，第三军医大学西南医院放射科） 【摘要】 目的 探查患者脑灰质结构存在异常方法 用基于体素的形态学方法（VBM，对比分析21例患者和21例年龄、性别及受教育程度相匹配的正常对照大脑灰质体积存在差异的脑区，并（Y-BOCS）（HAMD）及（HAMA）结果 患者正常对照相比大脑灰质的区域主要位于双侧眶额叶、前扣带回、丘脑以及小脑（P 0.05，FDR校正）， -0.63，P 0.001）。结论 。 【关键词】；磁共振成像；基于体素的形态学分析【】【】A volumetric magnetic resonance imaging study of gray matter structures in drug-naive patients with obsessive compulsive disorder Zhang Yang，Hou Jingming，Wu Wenjing，Li Haitao（Department of Radiology，Southwest Hospital，Third Military Medical University，Chongqing，400038，China） [Abstract] Objective To detect gray matter structural changes in drug-naive patients with obsessive compulsive disorder (OCD), and to investigate the correlations between abnormal gray matter volume and clinical symptoms. Methods Twenty-one OCD patients and 21 normal controls (matched with age, sex and education level) underwent structural MRI scan. The imaging data were analyzed using voxel-based morphometry method. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) ，Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA) were used to assess clinical symptoms. Results Compared to normal controls, the OCD patients showed signi?cantly decreased regional gray matter mainly in the bilateral orbitofrontal cortex, anterior cingulate cortex, right thalamus and cerebellum (P 0.05, FDR corrected). The volume of left orbitofrontal cortex in OCD patients showed a negative correlation with the total score in Y-BOCS (r = -0.63, P 0.001). Conclusion This study verifies that the structural abnormalities of the “cortical-striatal-thalamic-cortical” loops play a vital role in the pathogenesis of OCD. In addition, the cerebellum and other structural abnormalities may also be involved in the pathophysiology of OCD. [Key words] obsessive compulsive disorder；agnetic resonance imaging；oxel-based morphometry；rain atrophy；ray matter Supported by the National Natural Science