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AuroraA通过异常调节DNA损伤应答促进肿瘤放化疗抵抗
万方数据
目录
全文英文缩写索引·····-······-···············1
中文摘要·············-·················3
英文摘要································6
前言··································9
参考文献································11
第一部分Aurora．A促进细胞增殖，体外克隆形成以及细胞周期进展
引言································13
材料与方法··············-··············14
结果及结论·-···························21
第二部分 Aurora-A促进肿瘤放化疗抵抗
引言································24
材料与方法·······-·····················25
结果及结论·············-···············27
第三部分 Aurora-A引起肿瘤放化疗抵抗的机理研究
Aurora-A异常调节DNA损伤应答
引言································35
材料与方法·······························36
结果及结论······-·····················39
第二章Aurora-A上调ATM促进肿瘤放化疗抵抗
引言······························· ·42
材料与方法·····················-·······43
结果及结论··········-·················45
第三章Aurora-A下调BRCAl／2促进肿瘤放化疗抵抗
引言··········-···········-········48
材料与方法···························-49
结果及结论····························52
参考文献··-···························60
{寸论··-·············-···········-·····63
参考文献································65
综!述·····-····························67
参：考文献································75
致谢···············-··················82
论文独创性声明及论文使用授权说明····················83
万方数据
全文英文缩写索引
英文缩写 英文全称 中文全称
APS ammonium 过硫酸铵
peroxydisulfate
ATM ataxia mutated 毛细血管扩张性共
telangiectasia
protein 济失调突变蛋白
ATR ataxia and 共济失调毛细血管
telangieetasia
Rad3一related 张症Rad3相关蛋白
protein
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