arthroscopic optical coherence tomography in diagnosis of early arthritis早期关节炎的关节镜光学相干断层扫描诊断.pdfVIP

Hindawi Publishing Corporation Minimally Invasive Surgery Volume 2011, Article ID 671308, 6 pages doi:10.1155/2011/671308 Review Article Arthroscopic Optical Coherence Tomography in Diagnosis of Early Arthritis Michael J. O’Malley and Constance R. Chu Department of Orthopaedic Surgery, Cartilage Restoration Center, University of Pittsburgh Medical Center, BST 1640 200 Lothrop Street, Pittsburgh, PA 15213, USA Correspondence should be addressed to Constance R. Chu, chucr@ Received 28 October 2010; Revised 15 January 2011; Accepted 8 February 2011 Academic Editor: Stephen Kavic Copyright © 2011 M. J. O’Malley and C. R. Chu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Osteoarthritis (OA) is a progressive, debilitating disease that is increasing in prevalence. The pathogenesis of OA is likely multifactorial but ultimately leads to progressive breakdown of collagen matrix and loss of chondrocytes. Current clinical modalities employed to evaluate cartilage health and diagnose osteoarthritis in orthopaedic surgery include, radiography, MRI, and arthroscopy. While these assessment methods can show cartilage fissuring and loss, they are limited in ability to diagnose cartilage injury and degeneration prior breakdown of the articular surface. An improved clinical ability to detect subsurface cartilage pathology is important for development and testing of chondroprotective and chondrorestorative treatments because the pathological changes following surface breakdown are generally considered to be irreversible. Optical Coherence Tomography