associated factors for in-hospital mortality in patients with meningeal cryptococcosis and hiv infection at a local hospital in lima, peru相关因素脑膜隐球菌和艾滋病毒感染患者住院死亡率在当地一家医院在利马,秘鲁.pdfVIP

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associated factors for in-hospital mortality in patients with meningeal cryptococcosis and hiv infection at a local hospital in lima, peru相关因素脑膜隐球菌和艾滋病毒感染患者住院死亡率在当地一家医院在利马,秘鲁.pdf

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associated factors for in-hospital mortality in patients with meningeal cryptococcosis and hiv infection at a local hospital in lima, peru相关因素脑膜隐球菌和艾滋病毒感染患者住院死亡率在当地一家医院在利马,秘鲁

World Journal of AIDS, 2011, 1, 8-14 1 doi: 10.4236/wja.2011.11002 Published Online March 2011 (http://www.SciRP.org/journal/wja) Associated Factors for In-Hospital Mortality in Patients with Meningeal Cryptococcosis and HIV Infection at a Local Hospital in Lima, Peru 1 1 1 1 Canessa J.C. , Cabrera D. , Eskenazi J. , Samalvides F 1Cayetano Heredia University, Lima, Peru. Email: juan.canessa@upch.pe Received March 8th, 2011; revised March 17th, 2011; accepted March 18th, 2011. ABSTRACT Objective: To determine the associated factors for in-hospital mortality in patients with meningeal cryptococcosis and HIV infection at a local hospital in Lima, Peru Materials and methods : We carried out a case-control study by reviewing the medical histories available at a local hospital in Lima, Peru. We determined the factors associated with mortality using a logistic regression model. Results : The information of 90 patients was analyzed, 37 dead and 53 alive. In the multivariate analysis we found two variables associated with mortality: Glasgow at admission (OR = 4.55 (1.61 – 12.20), p = 0.01) and serum antigen titer greater than 1024 (OR = 20.48 (1.6 – 261.04, p = 0.02). The protective factor found was a longer hospitalization stay (OR = 0.80 (0.69 – 0.93, p = 0.005).Conclusions: A low Glasgow score and serum antigen titer greater than 1024 are associated factors with mortality, whereas hospitalization length is a protective factor. Keywords : Meningeal Cryptococcosis, Cryptococcus, HIV, Mortality, Death, Cryptococcal Meningitis 1. Introduction per year [12]. The most common signs and symptoms are: headache, Cryptococcosis is an opportunistic dise