association between depression and c-reactive protein抑郁和c反应蛋白之间的联系.pdfVIP

SAGE-Hindawi Access to Research Cardiology Research and Practice Volume 2011, Article ID 286509, 8 pages doi:10.4061/2011/286509 Clinical Study Association between Depression and C-Reactive Protein Yunsheng Ma,1 David E. Chiriboga,1 Sherry L. Pagoto,1 Milagros C. Rosal,1 Wenjun Li,1 1 ´ 2 1 3 Philip A. Merriam, James R. Hebert, Matthew C. Whited, and Ira S. Ockene 1 Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 01655, USA 2 Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA 3 Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA Correspondence should be addressed to Yunsheng Ma, Yunsheng.Ma@ Received 20 August 2010; Accepted 10 November 2010 Academic Editor: Demosthenes Panagiotakos Copyright © 2011 Yunsheng Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. Depression has been associated with increased cardiovascular disease risk, and a depression-related elevation of high sensitivity C-reactive protein (hs-CRP) has been proposed as a possible mechanism. The objective of this paper is to examine association between depression and high sensitivity C-reactive protein (hs-CRP). Methods. Subjects consisted of 508 healthy adults (mean age 48.5 years; 49% women, 88% white) residi