autoselection phenomenon in the normal cell clone undergoing differentiation from cell population heterogeneity to cancer phenotype via nonmutational changesautoselection现象在正常细胞克隆进行分化的细胞群异质性通过nonmutational癌症表型变化.pdfVIP
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autoselection phenomenon in the normal cell clone undergoing differentiation from cell population heterogeneity to cancer phenotype via nonmutational changesautoselection现象在正常细胞克隆进行分化的细胞群异质性通过nonmutational癌症表型变化
Journd cfT11eureticalMedione, Vol 2, p p 275-283 2000 OPA (Oversea5 Publishers Associat~on)N.V.
Repr~ntswallable directly from the pubhrher Published by l~censeunder
Photocopymg permitted by I~censeonly the Gordon and Breach Science
Publisher, Impnnt
Printed in Malaysia.
Autoselection Phenomenon in the Normal Cell Clone
Undergoing Differentiation: From Cell Population
Heterogeneity to Cancer Phenotype via Nonmutational
Changes
GALINA I. SOLYANIKa,*and ALEXANDER A. SERIKOV~
aInstitute of E-xperimentalPathology, Oncology and Radiohiology, Kiev 252022, Ukraine; b~ogalyubov1nstitl~te.fiwTheoreticul Physics
and Scientific Research Centre of Quantum Medicine Vidhuk, Kiev 252143, Ukraine
(Received 22 November 1998; Irz$nal form 9 August 1999)
The problern of regulation of the proliferation-differentiation processes is analysed in the
framework of the model of unipotential cell clone dynamics, assuming two alternative
ways (scenarios) of an every new-born cell development, which in the long run define
correspondingly the proliferating or differe
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