baseline factors predictive of slt response a prospective study基线因素预测slt反应的前瞻性研究.pdfVIP

Hindawi Publishing Corporation Journal of Ophthalmology Volume 2012, Article ID 642869, 5 pages doi:10.1155/2012/642869 Clinical Study Baseline Factors Predictive of SLT Response: A Prospective Study Robin Bruen,1 Mark R. Lesk,1, 2 and Paul Harasymowycz1 1 Department of Ophthalmology, University of Montreal, Montreal, QC, Canada 2 Maisonneuve-Rosemont Hospital Research Centre, Montreal, QC, Canada Correspondence should be addressed to Paul Harasymowycz, pavloh@ Received 25 February 2012; Accepted 13 May 2012 Academic Editor: Andrew G. Lee Copyright © 2012 Robin Bruen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. To study the response to Selective Laser Trabeculoplasty (SLT) according to baseline medical treatment, angle pigmentation, age, diagnosis (open-angle glaucoma or ocular hypertension), and baseline intraocular pressure (IOP). Methods. 74 eyes of 74 patients were enrolled in this study. Baseline characteristics were recorded for each patient. IOP in the treated and fellow eyes was measured at baseline, and 1 month, 6 months, and 12 months following SLT. IOP changes in the different groups were compared using two-way ANOVA and Pearson’s correlation. Results. The mean age of our cohort was 71 ± 10 years. The mean baseline IOP was 21.5 ±5 mmHg, and the mean change in IOP from baseline in the treated eye at one year was −4.67 ±3.40 mmHg. Higher baseline IOP was highly correlated with greater absolute IOP decrease. Prostaglandin analogue use at baseline was shown to be associated with a statistically decreased IOP-lowering response following SLT when corrected for basel