basic experimental pancreatitis models for beginners对于初学者来说基本实验胰腺炎模型.pdfVIP

Surgical Science, 2010, 1, 31-39 doi:10.4236/ss.2010.12007 Published Online October 2010 (http://www.SciRP.org/journal/ss) Basic Experimental Pancreatitis Models for Beginners 1 2 Baris D. Yildiz , Erhan Hamaloglu 1 Ankara Numune Teaching Hospital 6th General Surgery, Ankara,Turkey 2Hacettepe University Faculty of Medicine General Surgery Department, Sihhiye, Turkey E-mail : baris 104@, barisy@.tr Received July 6, 2010; revised August 3, 2010; accepted August 10, 2010 Abstract Efforts to find an ideal model for pancreatitis date back to 1960’s. Many models are suggested since then. Every model has its own advantages and disadvantages. Some of these models test etiology while others simulate the complications of pancreatitis. An ideal model which by itself demonstrates all aspects of pan- creatitis including systemic changes is yet to be described. In this review we tried to gather the basic, easy to construct models. Keywords: Pancreatitis, Experimental Models, Closed Duodenal Loop, Arginine Induced, Ex Vivo Perfusion Model, Duct Obstruction, Taurocholate Injection, Vascular Induced 1. Introduction to PD causing pancreatitis. Closed loop is constructed with duodenum surrounding the opening of the PD. Acute pancreatitis (AP) is inflammation of pancreatic This model was first described by Seidel and popular- tissue which can present in a wide spectrum ranging ized later by Pfeffer [1]. The first species used were dogs from edema of