bayesian analysis of a lipid-based physiologically based toxicokinetic model for a mixture of pcbs in rats贝叶斯分析lipid-based生理毒性动力学模型为基础的混合多氯联苯的老鼠.pdfVIP

Hindawi Publishing Corporation Journal of Toxicology Volume 2012, Article ID 895391, 10 pages doi:10.1155/2012/895391 Research Article Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats Alan F. Sasso,1, 2 Panos G. Georgopoulos,1 Sastry S. Isukapalli,1 and Kannan Krishnan3 1 Environmental and Occupational Health Sciences Institute, UMDNJ-RW Johnson Medical School, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA 2 Department of Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ 08854, USA 3 Departement de Sante Environnementale et Sante au Travail, 2375 Cote-Sainte-Catherine, Universite de Montreal, ´ ´ ´ ´ ´ Montreal, Road QC, Canada, H3C 3J7 Correspondence should be addressed to Sastry S. Isukapalli, sastry@ Received 12 August 2011; Revised 5 October 2011; Accepted 6 October 2011 Academic Editor: Jane C. Caldwell Copyright © 2012 Alan F. Sasso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A lipid-based physiologically based toxicokinetic (PBTK) model has been developed for a mixture of six polychlorinated biphenyls (PCBs) in rats. The aim of this study was to apply population Bayesian analysis to a lipid PBTK model, while incorporating an internal exposure-response model linking enzyme induction and metabolic rate. Lipid-based physiologically based toxicokinetic models are a subset of PBTK models that can simulate concentrations of highly lipophilic compounds in tissue lipids,