bone marrow stem cell derived paracrine factors for regenerative medicine current perspectives and therapeutic potential骨髓干细胞衍生的旁分泌因子目前再生医学观点和治疗的潜力.pdfVIP

Hindawi Publishing Corporation Bone Marrow Research Volume 2011, Article ID 207326, 14 pages doi:10.1155/2011/207326 Review Article Bone Marrow Stem Cell Derived Paracrine Factors for Regenerative Medicine: Current Perspectives and Therapeutic Potential Tom J. Burdon,1 Arghya Paul,1 Nicolas Noiseux,2 Satya Prakash,1 and Dominique Shum-Tim3, 4 1 Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, Duff Medical Building, 3775 University Street, McGill University, QC, Canada H3A 2B4 2 D`epartment de Chirurgie Cardiaque, Centre Hospitalier de l’Universit´e de Montr´eal, Pavillon Hˆotel-Dieu, Universit´e de Montr´eal, Montr´eal, QC, Canada H3C 3J7 3 Divisions of Cardiac Surgery and Surgical Research, The Montreal General Hospital, McGill University Health Center, QC, Canada H3G 1A4 4 The Royal Victoria Hospital, Suite S8.73.B, 687 Pine Avenue West, Montr´eal, QC, Canada H3A 1A1 Correspondence should be addressed to Dominique Shum-Tim, dshumtim@yahoo.ca Received 31 August 2010; Accepted 12 October 2010 Academic Editor: Helen A. Papadaki Copyright © 2011 Tom J. Burdon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. During the past several years, there has been intense research in the field of bone marrow-derived stem cell (BMSC) therapy to facilitate its translation into clinical setting. Although a lot has been accomplished, plenty of challenges lie ahead. Furthermore, there is a growing body of evidence showing that administration of BMSC-derived conditioned media (BMSC-CM) can recapitulate the benefic