bicuspid aortic valve disease a comprehensive review二叶主动脉瓣疾病的全面审查.pdfVIP

Hindawi Publishing Corporation Cardiology Research and Practice Volume 2012, Article ID 196037, 7 pages doi:10.1155/2012/196037 Review Article Bicuspid Aortic Valve Disease: A Comprehensive Review Ify Mordi and Nikolaos Tzemos Institute for Cardiovascular Research, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK Correspondence should be addressed to Nikolaos Tzemos, niko.tzemos@glasgow.ac.uk Received 27 January 2012; Accepted 26 March 2012 Academic Editor: Ani C. Anyanwu Copyright © 2012 I. Mordi and N. Tzemos. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Bicuspid aortic valve is the commonest congenital cardiac abnormality in the general population. This paper article will discuss our current knowledge of the anatomy, pathophysiology, genetics, and clinical aspects of bicuspid aortic valve disease. 1. Introduction The exact pathogenesis of the formation of bicuspid aortic valves is not yet fully understood. It is thought there is Bicuspid aortic valve (BAV) is the commonest congenital certainly a genetic component, especially given the associ- cardiac abnormality with an estimated prevalence of 1-2% ation of BAV with other congenital abnormalities such as [1]. It is almost 3 times more common in males than females coarctation of the aorta. In summary however, the BAV is [2]. Adverse cardiovascular outcomes in patients with BAV formed by fusion of the