brain natriuretic peptide production and secretion in inflammation脑利钠肽生产和分泌炎症.pdfVIP

Hindawi Publishing Corporation Journal of Transplantation Volume 2012, Article ID 962347, 7 pages doi:10.1155/2012/962347 Review Article Brain Natriuretic Peptide Production and Secretion in Inflammation Tsuneo Ogawa and Adolfo J. de Bold Cardiovascular Endocrinology Laboratory, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, Canada K1Y 4W7 Correspondence should be addressed to Adolfo J. de Bold, adebold@ottawaheart.ca Received 19 June 2012; Accepted 7 November 2012 Academic Editor: Gaetano Ciancio Copyright © 2012 T. Ogawa and A. J. de Bold. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Gene expression and secretion of the cardiac polypeptide hormones atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) are simultaneously upregulated in various cardiac disorders such as congestive heart failure, ischemic heart disease, and hypertensive heart disease, in which hemodynamic or neuroendocrine changes are key components in the progression of disease. However, during acute cardiac allograft rejection, plasma BNP levels are increased but not those of ANF. Successful treatment of the rejection episode decreases the elevated plasma BNP to prerejection values suggesting that substances related to inflammation may selectively influence BNP gene expression. Indeed, cytokines such as TNFα and IL-1β selectively stimulate cardiac BNP at the transcriptional and translational levels in cardiomyocyte cultures without affecting ANF. This selective BNP increase is seen in vivo, in addition to acute cardiac allograft rejection, in several circumstances where inflammation significantl