原创力文档biomarkers and depressive symptoms in a sample of cognitively intact and alzheimer’s disease elderly males生物标志物和抑郁症状在认知的完整的样本和阿尔茨海默病的老年男性.pdfVIP
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biomarkers and depressive symptoms in a sample of cognitively intact and alzheimer’s disease elderly males生物标志物和抑郁症状在认知的完整的样本和阿尔茨海默病的老年男性
Neuroscience Medicine, 2011, 2, 306-312
doi:10.4236/nm.2011.24040 Published Online December 2011 (http://www.SciRP.org/journal/nm)
Biomarkers and Depressive Symptoms in a Sample
of Cognitively Intact and Alzheimer’s Disease
Elderly Males
1,2* 1 3 1 2,4
James R. Hall , Hoa T. Vo , Leigh A. Johnson , Scott Winter , Robert C. Barber ,
Sid E. O’Bryant5,6
1Department of Psychiatry and Neuroscience, University of North Texas Health Sciences Center, Fort Worth, USA; 2Institute for
Aging and Alzheimer’s Disease Research, University of North Texas Health Sciences Center, Fort Worth, USA; 3Texas Tech Uni-
versity Health Sciences Center, Laura W. Bush Institute for Women’s Health Department of Family and Community Medicine,
Lubbock, USA; 4Department of Pharmacology and Neuroscience, University of North Texas Health Sciences Center, Fort Worth,
USA; 5F. Marie Hall Institute for Rural Community Health, Texas Tech Health Sciences Center, Lubbock, USA; 6Department of
Neurology, Texas Tech University Health Sciences Center, Lubbock, USA.
*
E-mail: james.hall@
Received October 6th, 2011; revised November 18th, 2011; accepted November 26th, 2011.
ABSTRACT
Serum-based biomarkers and GDS-30 score and subscales of depressive symptoms were examined in a cross-sectional
sample of 81 elderly men drawn from the TARCC cohort. Measurements included neuropsychological assessment and
serum. Thirty three patients met consensus diagnosis for probable AD and forty eight were cognitively intact. Although
initial regression analysis of all subjects showed significant relationships between depression and specific biomarkers,
analyses based on diagnosis indicated that none of the biomarkers were significantly associated with depression among
the controls. Among AD males MIF was significantly associated with
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