原创力文档biomarkers and echocardiography in the postoperative course of pulmonary resection surgery生物标志物和超声心动图在术后的肺切除手术.pdfVIP
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biomarkers and echocardiography in the postoperative course of pulmonary resection surgery生物标志物和超声心动图在术后的肺切除手术
Open Journal of Thoracic Surgery, 2011, 1, 1-8 1
doi:10.4236/ojts.2011.11001 Published Online September 2011 (http://www.SciRP.org/journal/ojts)
Biomarkers and Echocardiography in the
Postoperative Course of Pulmonary
Resection Surgery
1 1 2 3 2
David Andaluz-Ojeda , Francisco Gandía , Jose Luis Duque , Itziar Gómez , Begona De Gregorio ,
Jose Alberto San Román3, Eduardo Villacorta3
1Department of Intensive Care Medicine, Hospital Clínico Universitario, Valladolid, Spain; 2Deparment of Thoracic Surgery, Hospi-
tal Clínico Universitario, Valladolid, Spain; 3Deparment of Cardiology, Hospital Clínico Universitario, Valladolid, Spain.
Email: davidandaluz78@yahoo.es
Received August 4th, 2011; revised August 28th, 2011; accepted September 7th, 2011.
ABSTRACT
Background : The existence of different degrees of inflammatory reaction and right ventricular dysfunction after pul-
monary resection is well known, though its detection and clinical relevance have not been sufficiently evaluated. The
introduction of new biomarkers, particularly brain natriuretic peptide (BNP) and its prohormone (proBNP ), together
with dynamic imaging techniques such as echocardiography, could prove useful in assessing such response. The aim of
this study is to describe the kinetic curve of these biomarkers during uncomplicated pulmonary resection surgery. Fur-
themore we have studied the right ventricular function by echocardiography in these patients. Methods : Demographic
data, antecedents and certain perioperative parameters, as well as plasma proBNP, troponin T and C-reactive protein
(CRP) levels, were recorded in 38 patients who underwent pneumonectomy (n = 13 ) and lobectomy (n = 25), before
and 24, 48 and 72 hours after the opera
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