原创力文档biomarkers and atrial fibrillation a new paradigm for assessing the progression of left atrial endocardial remodelling生物标志物和心房纤维性颤动的新范式评估左心室心内膜改造的进展.pdfVIP
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biomarkers and atrial fibrillation a new paradigm for assessing the progression of left atrial endocardial remodelling生物标志物和心房纤维性颤动的新范式评估左心室心内膜改造的进展
Open Journal of Clinical Diagnostics, 2012, 2, 18-22 OJCD
/ 10.4236/ojcd.2012.22004 Published Online June 2012 (http://www.SciRP.org/journal/ojcd/)
Biomarkers and atrial fibrillation: A new paradigm for
assessing the progression of left atrial endocardial
remodelling
1 2
Philippe Chevalier , Alina Scridon
1Hospices Civils de Lyon, Hôpital Louis Pradel, Service de Rythmologie, Lyon, France
2University of Medicine and Pharmacy of Targu Mures, Targu Mures, Romania
Email: philippe.chevalier@chu-lyon.fr, alinascridon@
Received 29 December 2011; revised 13 February 2012; accepted 25 February 2012
ABSTRACT sistent and permanent atrial fibrillation represent three
different stages of the same pathophysiological process
Atrial fibrillation is a heterogeneous disorder that is
or whether they represent three distinct disorders. Mark-
usually characterized by paroxysmal onset, particu-
ers that predict the clinical progression of atrial fibrilla-
larly in patients without structural heart disease. De-
tion and its complications are yet to be defined.
fining biological markers of atrial remodelling would
help identify patients at high risk who would benefit 2. PREDICTORS OF ATRIAL
most from prophylactic treatment and careful moni- FIBRILLATION PROGRESSION
toring. Biomarkers of atrial fibrillation progression
would be helpful for following patients that present A number
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