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Hindawi Publishing Corporation Journal of Oncology Volume 2011, Article ID 632870, 8 pages doi:10.1155/2011/632870 Research Article Breast and Ovarian Cancer Risk due to Prevalence of BRCA1 and BRCA2 Variants in Pakistani Population: A Pakistani Database Report Ayesha Farooq, Abdul Khaliq Naveed, Zahid Azeem, and Tausif Ahmad Department of Biochemistry and Molecular Biology, National University of Sciences and Technology, Rawalpindi 46000, Pakistan Correspondence should be addressed to Zahid Azeem, paym zahid@ Received 23 February 2010; Revised 2 December 2010; Accepted 25 January 2011 Academic Editor: M. Steven Piver Copyright © 2011 Ayesha Farooq et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Pakistani population has a very rich anthrogeneological background with waves of migration from neighboring regions. Incidence rates of breast and ovarian cancer in Pakistan are on such a rapid rise that it is necessary to check the contributory factors, genetic and nongenetic. An insight into the prevalence data emphasizes the formulation of a BRCA1 and BRCA2 database for the Pakistani population. Method. In this study conducted by authors, data from diagnosed cases of both sporadic and inherited female breast and ovarian cancer cases was gathered after performing molecular genetic analysis by screening for alterations in the coding sequence of the BRCA gene. The region of interest was analyzed by the aid of various molecular biology tools such as automated DNA sequencer. Bioinformatics software was used to interpret the results, and database was prepared. Results. Mutational s