cancer chemoprevention through the induction of apoptosis by natural compounds癌症化学预防自然化合物通过诱导细胞凋亡.pdfVIP

Vol.3, No.2, 156-173 (2012) Journal of Biophysical Chemistry /10.4236/jbpc.2012.32018 Cancer chemoprevention through the induction of * apoptosis by natural compounds 1 2 1 1,3# Toshiya Kuno , Testuya Tsukamoto , Akira Hara , Takuji Tanaka 1Department of Tumor Pathology, Graduate School of Medicine, Gifu University, Gifu, Japan; #Corresponding Author: takutt@toukaisaibou.co.jp 2Department of Pathology, Fujita Health University School of Medicine, Dengakugakubo, Kutsukake-cho, Toyoake, Japan 3The Tohkai Institute of Cytopathology: Cancer Research and Prevention (TCI-CaRP), Minami-uzura, Gifu, Japan Received 26 January 2012; revised 28 February 2012; accepted 15 March 2012 ABSTRACT of a high rich in fruit and vegetable reduces the risk of several types of cancer [1]. Intake of fruit and vegetables As cell and tissue homeostasis are mediated by has been successfully used in the prevention of chronic the balance between proliferation and apoptosis, diseases associated with oxidative stress conditions, in- controlling this balance is important for cancer cluding cancer [2,3]. The cancer preventing properties of chemoprevention. Cancer chemoprevention can fruit and vegetables have been ascribed, at least in part, be achieved by the use of natural, synthetic or