cationic polypeptides in a concept of oppositely charged polypeptides as prevention of postsurgical intraabdominal adhesions阳离子多肽的电荷相反的概念多肽作为预防手术后的腹部.pdfVIP

J. Biomedical Science and Engineering, 2011, 4, 200-206 JBiSE doi:10.4236/jbise.2011.43028 Published Online March 20 11 (http://www.SciRP.org/journal/jbise/). Cationic polypeptides in a concept of oppositely charged po- lypeptides as prevention of postsurgical intraabdominal adhe- sions Karolin Isaksson, Daniel Åkerberg, Katarzyna Said, Bobby Tingstedt Department of Surgery, University Hospital of Lund, Sweden. Email: bobby.tingstedt@med.lu.se Received 29 November 2010; revised 3 January 2011; accepted 5 January 20 11. ABSTRACT 1. INTRODUCTION Background: Two differently charged polypeptides, Postoperative abdominal adhesion formation is a sig- α-poly-L-lysine and poly-L-glutamate, have previ- nificant clinical problem worldwide, especially follow- ously been shown to effectively reduce postoperative ing lower abdominal surgery [1,2]. Adhesions contain intraabdominal adhesions. Though α-poly-L-lysine fibrotic tissue that can create bridges between bowels, showed toxicity in doses too close to the lowest the- organs and the abdominal wall, thus creating intraab- rapeutic dose, the aim in the present study was to dominal problems. Abdominal adhesions are not only the investigate the possible antiadhesive effect of another leading cause of small bowel obstruction, a common four cationic polypeptides. Materials/Methods : 125 diagnosis often demanding surgical treatment, but also mice were studied with a standardized and repro- cause abdominal pain and female infertility [3]. ducible adhesion model and given epsi