characterization and biodegradation studies for interpenetrating polymeric network (ipn) of chitosan-amino acid beads表征和生物降解研究互穿聚合物网络(ipn)chitosan-amino酸珠子.pdfVIP

Journal of Biomaterials and Nanobiotechnology, 2011, 2, 71-84 71 doi:10.4236/jbnb.2011.21010 Published Online January 2011 (http://www.SciRP.org/journal/jbnb) Characterization and Biodegradation Studies for Interpenetrating Polymeric Network (IPN) of Chitosan-Amino Acid Beads 1 1 2 Manjusha Rani , Anuja Agarwal , Yuvraj Singh Negi 1Department of Chemistry, J. V. Jain College, Saharanpur (U.P.), India; 2Polymer Science and Technology Program, Department of Paper Technology, Saharanpur Campus, Indian Institute of Technology, Roorkee, Saharanpur (U.P.), India Email: dr_yuvrjas_negi@yahoo.co.in th th th Received December 4 , 2010; revised December 16 , 2010; accepted December 20 , 2010. ABSTRACT The paper describes the synthesis of pH sensitive interpenetrating polymeric network (IPN) beads composed of chitosan, glycine, glutamic acid, cross linked with glutaraldehyde and their use for controlled drug release. The drug was loaded into beads by varying their composition such as, amount of crosslinker glutaraldehyde, ratio of chitosan, glycine and glutamic acid. The beads were characterized by fourier transform infrared (FTIR) spectroscopy to confirm the cross linking reaction and drug interaction with crosslinked polymer in beads, Scanning Electron Microscopy (SEM) to un- derstand the surface morphology and Differential scanning calorimetry (DSC) to find out the thermal stability of beads. X-Ray Diffraction (XRD ) investigation was carried out to determine the crystalline nature of drug after loading into chitosan-glycine-glutamic acid IPN beads. Results indicated amorphous dispersion of chlorpheniramine maleate (CPM) in the polymeric matrix. The swelling behavior of the beads at differen