clinico-haematological profile of acute megakaryoblastic leukaemia report of five casesclinico-haematological概要急性megakaryoblastic白血病5例报告.pdfVIP

Hindawi Publishing Corporation Advances in Hematology Volume 2009, Article ID 461912, 4 pages doi:10.1155/2009/461912 Case Report Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases Sunita Sharma, Anita Nangia, Sonal Jain Malhotra, Shashi Narayan, Aparna Harbhajanka, and Sarika Singh Department of Pathology, Lady Hardinge Medical College, New Delhi 110001, India Correspondence should be addressed to Anita Nangia, dranangia@ Received 24 September 2008; Revised 14 December 2008; Accepted 20 December 2008 Recommended by Maher Albitar Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia. Although known as a distinct entity for a very long time, because of lack of distinct clinical features and morphological criteria, it is difficult to diagnose this variant correctly. We herein present the clinical, morphological, cytochemical, and immunocytochemical features of five cases of AMKL. Certain morphological features such as presence of abnormal platelet count, giant platelets, and cytoplasmic blebbing in blasts were found to be important pointers towards the diagnosis. However, none of the features were found to be consistent and thus morphological diagnosis has to be confirmed by cytochemistry and immunocytochemistry. Copyright © 2009 Sunita Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. Introduction Wright’s stained peripheral smears and bone marrow aspirate (BMA) smears were examined. Bone