clinico-pathological characterization of hereditary, familial and sporadic prostate cancer二特征的遗传性、家族和零星的前列腺癌.pdfVIP

Open Journal of Urology, 2012, 2, 38-44 /10.4236/oju.2012.22008 Published Online May 2012 (http://www.SciRP.org/journal/oju) Clinico-Pathological Characterization of Hereditary, Familial and Sporadic Prostate Cancer Diem Nguyen Bentzon, Anne Sofie Lynnerup, Michael Borre Department of Urology, Aarhus University Hospital Skejby, Aarhus, Denmark Email: diem.bentzon@dadlnet.dk Received January 12, 2012; revised February 7, 2012; accepted February 28, 2012 ABSTRACT Aim: To characterize familial prostate cancer including hereditary prostate cancer and assess the disease-free survival following radical prostatectomy. Methods: A self-administered written questionnaire was forwarded to 709 prostatec- tomized patients from the Aarhus Prostate Cancer Study containing questions about cases of prostate cancer (PC), age at diagnosis, vital status, and age at death for all first-degree relatives. Patients were then divided into groups according to their family history: hereditary prostate cancer (HPC), familial prostate cancer (FPC), and sporadic prostate cancer (SPC) groups. The information from a subset of both FPC (n = 17) and SPC (n = 17) groups were validated in the Dan- ish Cancer Register and the Civil Registration System. Between groups, we described the association of age, prostate- specific antigen (PSA), postoperative Gleason score and T Stage. A Kaplan-Meier curve demonstrated postoperative disease-free survival in each group. Results: The response rate was 81% (574/709). About 21% of the patients were categorized in the FPC group, of which 7% were identified as having HPC. The median follow-up time was 63 months for HPC, 65 months for FPC and 88 months for SPC. Overall, there was no significant difference between groups in clinical features and disease-free survival except th