原创力文档comparative analysis of various modularization algorithms and species specific study of vegf signaling pathways比较分析各种模块化算法和物种的特定研究vegf信号通路.pdfVIP
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comparative analysis of various modularization algorithms and species specific study of vegf signaling pathways比较分析各种模块化算法和物种的特定研究vegf信号通路
J. Biomedical Science and Engineering, 2010, 3, 931-941 JBiSE
doi:10.4236/jbise.2010.310124 Published Online October 2010 (http://www.SciRP.org/journal/jbise/).
Comparative analysis of various modularization algorithms
and species specific study of VEGF signaling pathways
Namrata Tomar, Losiana Nayak, Rajat K. De
Machine Intelligence Unit, Indian Statistical Institute, Kolkata, India.
Email: namrata_t@isical.ac.in; losiana_t@isical.ac.in; rajat@isical.ac.in
Received 24 August 2009; received 9 September 2009; accepted 30 August 2010.
ABSTRACT way, Complexity Value, KEGG Database, Modulariza-
tion, Newman’s Community Finding Algorithm, Ker-
In biology, signal transduction refers to a process nighan-Lin’s Algorithm, Farhat’s Algorithm, and Greedy
by which a cell converts one kind of signal or sti- Algorithm.
mulus into another. It involves ordered sequences of
biochemical reactions inside the cell. These cas- 1. INTRODUCTION
cades of reactions are carried out by enzymes and
activated by second messengers. Signal transduc- The ability of cells to receive and act on signals from
tion pathways are complex in nature. Each pathway beyond the plasma membrane is fundamental to life.
is responsible for tuning one or more biological This ability of cells to respond correctly to their micro-
functions in the intracellular environment as well as environment is the basis of development, tissue repair,
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