原创力文档comparison of disk diffusion and etest methods to determine the susceptibility of staphylococcus aureus circulating in riyadh, saudi arabia to fusidic acid比较的磁盘扩散和基线测试方法确定金黄色葡萄球菌的敏感性循环在利雅得,沙特阿拉伯梭链孢酸.pdfVIP
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comparison of disk diffusion and etest methods to determine the susceptibility of staphylococcus aureus circulating in riyadh, saudi arabia to fusidic acid比较的磁盘扩散和基线测试方法确定金黄色葡萄球菌的敏感性循环在利雅得,沙特阿拉伯梭链孢酸
Hindawi Publishing Corporation
International Journal of Microbiology
Volume 2012, Article ID 391251, 4 pages
doi:10.1155/2012/391251
Research Article
Comparison of Disk Diffusion and Etest Methods to
Determine the Susceptibility of Staphylococcus aureus
Circulating in Riyadh, Saudi Arabia to Fusidic Acid
Ali M. Somily,1 David R. Peaper,2, 3 Elijah Paintsil,4 and Thomas S. Murray2, 5
1 Department of Pathology, Microbiology Unit, College of Medicine, King Saud University and King Khalid University Hospital,
Riyadh 11411, Saudi Arabia
2 Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06510, USA
3 Pathology and Laboratory Medicine Service, Veteran Aff airs (VA) Connecticut Healthcare System, West Haven, CT 06516, USA
4 Departments of Pediatrics and Pharmacology, Yale School of Medicine, New Haven, CT 06510, USA
5 Department of Medical Sciences, The Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden,
CT 06518-7908, USA
Correspondence should be addressed to Thomas S. Murray, thomas.murray2@
Received 12 March 2012; Revised 24 May 2012; Accepted 7 June 2012
Academic Editor: John Tagg
Copyright © 2012 Ali M. Somily et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fusidic acid is a common therapy for staphylococcal infections in Saudi Arabia, but reports have suggested high rates of resistance
among clinical isolates. Susceptibility testing of S. aureus to fusidic acid is further complicated by the lack of consensus on mean
inhibitory concentrations (MIC) and disk diffusion cutoffs to determine resistance. The purpose of this study was to determine
the c
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